ATAI Investor Presentation Deck
Substance Use Disorder (SUD)
Opportunity Overview
Substance use disorders are highly prevalent disorders
characterized by an inability to control the use of a legal or
illegal drug, medication or another psychoactive compound
Substance
Use
Disorder
SUD)
SUD in numbers
Opioid
Use
Disorder
(OUD)
~20m+
US sufferers of SUD in 2019
~70k
US deaths from opioid drug
overdose in 2020³
$787bn
Societal cost associated with OUD in
the US4
AN ONGOING PANDEMIC
~3m
~75%
-93,000
2
Number of OUD sufferers in US
Approximately 3 million individuals in the US suffered from OUD
in 2020²
High relapse rates
Approximately ~75% of patients undergoing OUD therapy
experience relapse within one year5
31
Drug overdose deaths increase -30%
COVID-19 severely exacerbated the crisis for those with a SUD;
drug overdose deaths increase ~30% with close to 93,000 deaths in
2020; nearly 70,000 of which involved opioids
Treatment options for OUD
Currently the only two treatment options for OUD are synthetic
opioid receptor agonists (methadone & buprenorphine) and
opioid antagonists (naltrexone and naloxone)
(1) SAMSHA - Key Substance Use and Mental Health Indicators in the United States: Results from the 2019 National Survey on Drug Use and Health) (4) Murphy, "The cost of opioid use disorder and the value of aversion" (2020)
(2) Azadfard et al., "Opioid Addiction" (2020)
(5) Sinha, "New Findings on Biological Factors Predicting Addiction Relapse Vulnerability" (2011)
(3) Ahmad FB, Rossen LM, Sutton P. "Provisional drug overdose death counts". National Center for Health Statistics (2021)View entire presentation