Taysha IPO Presentation Deck
The microtubule associated protein tau (MAPT) plays
a key role in numerous neurodegenerative disorders
Mutations in MAPT lead to changes in the
propensity of tau to form toxic aggregates
Tauopathies refer to a wide range of diverse
diseases characterized by the aggregation of tau
in neurons and/or glia, including:
- Alzheimer's disease (AD);
Progressive supranuclear palsy (PSP);
Frontotemporal dementia (FTD), and;
Parkinsonism linked to chromosome 17 (FTDP-17)
-
The estimated prevalence of these tauopathies,
excluding AD is 40,000 patients in the US and EU
AAV9+
IXAT
Anti-Tau-miRNA +
Intrathecal
delivery
PID (3R)
MAPT MUTATIONS
CBD (4R)
Tau aggregation
9% = 4-2-
10 11
FTLD-tau SUBTYPES
1
PSP (4R)
13
GGT (4R)
Cell-cell transmission
58View entire presentation