Investor Presentation

18 Systemic Sclerosis (SSc) at a Glance D S 6 * Images (top) Provided by the Scleroderma Foundation Lenabasum Sclero = stone, Derma = skin Mortality: Most lethal of the systemic autoimmune diseases, 40-60% 10-year survival with more severe disease Pathogenesis: Autoimmune disease with chronic activation of innate immune responses; organ inflammation, fibrosis and vascular damage Common Symptoms: Fatigue, anorexia, weight loss; tight, painful, itchy skin; shortness of breath; swallowing problems, reflux; painful joints and tendons; Raynaud's Current standard of care: Immunosuppressives with significant toxicity

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