Valneva IPO Presentation Deck

Lyme Disease Is a Major Health Issue Severe Tick-transmitted Infection, Increasingly Common in the US and Europe Early signs include flu-like symptoms¹ and Erythema migrans rash² which, if left untreated, can spread to joints (arthritis), heart (carditis) and cause neurological problems No available treatment to protect against Lyme disease Global market estimated to reach $1 billion by 2030 Direct medical costs in the U.S. estimated up to $1.3 billion - indicating an attractive health economic benefit³ 2001 Valneva - Roadshow Presentation Spread of Lyme Across the US4 'Fever, chills, headache, fatigue, muscle and joint aches, swollen lymph nodes. 2 Occurs in approx. 70-80% of infected persons, Adrion, E. et al PLOS ONE Feb 2015. *Centers for Disease Control and Prevention April 2021

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