Kymera Investor Day Presentation Deck

Targeted Protein Degradation Human Proteome KYMERA Targeted Protein Degradation Next Potential Breakthrough Modality to Expand Drugged Proteome ✓ ✓ ✓ ✓ Undrugged Opportunity ©2021 KYMERA THERAPEUTICS, INC. Drugged Traditional Small Molecule Undruggable Targets Scaffold, transcript factor, multiple functions Efficient Development / Manufacturing Systemic Exposure Oral Bioavailability KYMERA R&D DAY - December 16th, 2021 Existing Modalities Antibody 044 Antisense X X X Cell/Gene Therapy RNAi PAGE 86

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