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argenx SE Investor Day Presentation Deck

FcRn Plays a Key Role in IgG and Albumin Homeostasis Studies have shown: 1 2 3 Circulating antibodies are taken up in the cell via pinocytosis. In the endosome, IgG antibodies bind to FcRn¹,2 argenx Unbound IgGs enter the lysosomal degradation pathway, while FcRn-bound IgGs are rescued from degradation ¹,2 The IgG antibodies bound by FcRn are then released back into circulation, thereby extending their half-life ¹,2 Albumin is recycled by FcRn, independently of IgG FcRn, neonatal fragment crystallizable receptor; IgG, immunoglobulin G. (1) Sesarman et al., Cell Mol Life Sci. 2010; (2) Habib et al., Supp Neuro Review. 2020. 1 Endothelial Cell 2 Lysosome 3 Endosome IgG Autoantibody IgG Antibody FcRn Albumin 17

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