OmniAb Investor Presentation Deck

Common Light Chain Platforms for Bispecific Antibodies STANDARD IgG FORMAT TO DE-RISK DOWNSTREAM DEVELOPMENT* OmniFlic Rearranged IgVK3-15/JK1 JK2-5 0000- IgKC Rearranged human VK3-15 light chain combined with diversifying heavy chain +The Evolution of Bispecifc Antibodies, Nimish Gera https://doi.org/10.1080/14712598.2022.2040987 Bispecifics are a growing area of therapeutics (20% of mAbs in clinic) ~30% of new OmniAb programs seek to use OmniFlic or OmniClic OmniClic Simple reformatting from monospecific into bispecific for efficient production P Bispecific IgG IgVK3-15/JK1 "Germlining" human VK3-15 light chain combined with diversifying heavy chain Monospecific IgG 18 Common light chain for OmniFlic and OmniClic allows interchangeability between the platforms OmniAb

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