#1BIONTECH 2nd Quarter 2022 Financial Results & Corporate Update August 8, 2022 COVID-19 HOMINO12 HOEINO12#2This Slide Presentation Includes Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, but not limited to, statements concerning: our expected revenues and net profit related to sales of our COVID-19 vaccine, referred to as COMIRNATY® where approved for use under full or conditional marketing authorization, in territories controlled by our collaboration partners, particularly for those figures that are derived from preliminary estimates provided by our partners; our pricing and coverage negotiations with governmental authorities, private health insurers and other third-party payors after our initial sales to national governments; the future commercial demand and medical need for initial or booster doses of a COVID- 19 vaccine; competition from other COVID-19 vaccines or related to our other product candidates, including those with different mechanisms of action and different manufacturing and distribution constraints, on the basis of, among other things, efficacy, cost, convenience of storage and distribution, breadth of approved use, side-effect profile and durability of immune response; the rate and degree of market acceptance of our COVID-19 vaccine and, if approved, our investigational medicines; the initiation, timing, progress, results, and cost of our research and development programs, including those relating to additional formulations of our COVID-19 vaccine, and our current and future preclinical studies and clinical trials, including statements regarding the timing of initiation and completion of studies or trials and related preparatory work, the period during which the results of the trials will become available and our research and development programs; the timing of and our ability to obtain and maintain regulatory approval for our product candidates; the ability of BNT162b2 to prevent COVID-19 caused by emerging virus variants; our and our counterparties' ability to manage and source necessary energy resources; our ability to identify research opportunities and discover and develop investigational medicines; the ability and willingness of our third-party collaborators to continue research and development activities relating to our development candidates and investigational medicines; the impact of the COVID-19 pandemic on our development programs, supply chain, collaborators and financial performance; unforeseen safety issues and claims for personal injury or death arising from the use of our COVID-19 vaccine and other products and product candidates developed or manufactured by us; our ability to progress our Malaria, Tuberculosis and HIV programs, including timing for selecting clinical candidates for these programs and the commencement of a clinical trial, as well as any data readouts; the nature and duration of support from the World Health Organization, the European Commission and other organizations with establishing infrastructure; the development of sustainable vaccine production and supply solutions on the African continent, including our BioNTainers, and the nature and feasibility of these solutions; our estimates of research and development revenues, commercial revenues, cost of sales, research and development expenses, sales and marketing expenses, general and administrative expenses, capital expenditures, income taxes, shares outstanding; our ability and that of our collaborators to commercialize and market our product candidates, if approved, including our COVID-19 vaccine; our ability to manage our development and expansion; regulatory developments in the United States and foreign countries; our ability to effectively scale our production capabilities and manufacture our products, including our target COVID-19 vaccine production levels, and our product candidates; and other factors not known to us at this time. In some cases, forward-looking statements can be identified by terminology such as "will," "may," "should," "expects," "intends," "plans," "aims," "anticipates," "believes," "estimates," "predicts," "potential," "continue," or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. The forward-looking statements in this presentation are neither promises nor guarantees, and you should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, many of which are beyond BioNTech's control and which could cause actual results to differ materially from those expressed or implied by these forward-looking statements. You should review the risks and uncertainties described under the heading "Risk Factors" in our quarterly report for the three months ended June 30, 2022 and in subsequent filings made by BioNTech with the SEC, which are available on the SEC's website at https://www.sec.gov/. Except as required by law, BioNTech disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this presentation in the event of new information, future developments or otherwise. These forward-looking statements are based on BioNTech's current expectations and speak only as of the date hereof. 2 BIONTECH#3Safety Information COMIRNATYⓇ (the Pfizer-BioNTech COVID-19 vaccine) has been granted conditional marketing authorization (CMA) by the European Commission to prevent coronavirus disease 2019 (COVID-19) in people from 5 yrs of age. The vaccine is administered as a 2-dose series, 3 weeks apart. In addition, the CMA has been expanded to include a booster dose (third dose) at least 6 months after the second dose in individuals 18 yrs of age and older. For immunocompromised individuals, the third dose may be given at least 28 days after the second dose. The European Medicines Agency's (EMA's) human medicines committee (CHMP) has completed its rigorous evaluation of COMIRNATY®, concluding by consensus that sufficiently robust data on the quality, safety and efficacy of the vaccine are now available. IMPORTANT SAFETY INFORMATION: Events of anaphylaxis have been reported. Appropriate medical treatment and supervision should always be readily available in case of an anaphylactic reaction following the administration of the vaccine. Very rare cases of myocarditis and pericarditis have been observed following vaccination with Comirnaty. These cases have primarily occurred within 14 days following vaccination, more often after the second vaccination, and more often in younger men. Available data suggest that the course of myocarditis and pericarditis following vaccination is not different from myocarditis or pericarditis in general. Anxiety-related reactions, including vasovagal reactions (syncope), hyperventilation or stress-related reactions (e.g. dizziness, palpitations, increases in heart rate, alterations in blood pressure, tingling sensations and sweating) may occur in association with the vaccination process itself. Stress-related reactions are temporary and resolve on their own. Individuals should be advised to bring symptoms to the attention of the vaccination provider for evaluation. It is important that precautions are in place to avoid injury from fainting. • The efficacy, safety and immunogenicity of the vaccine has not been assessed in immunocompromised individuals, including those receiving immunosuppressant therapy. The efficacy of COMIRNATY® may be lower in immunosuppressed individuals. ● 3 · • As with any vaccine, vaccination with COMIRNATY® may not protect all vaccine recipients. Individuals may not be fully protected until 7 days after their second dose of vaccine. In clinical studies, adverse reactions in participants 16 yrs of age and older were injection site pain (> 80%), fatigue (> 60%), headache (> 50%), myalgia and chills (> 30%), arthralgia (> 20%), pyrexia and injection site swelling (> 10%) and were usually mild or moderate in intensity and resolved within a few days after vaccination. A slightly lower frequency of reactogenicity events was associated with greater age. • The overall safety profile of COMIRNATY® in participants 5 to 15 yrs of age was similar to that seen in participants 16 yrs of age and older. • The most frequent adverse reactions in children 5 to 11 yrs of age were injection site pain (>80%), fatigue (>50%), headache (>30%), injection site redness and swelling (>20%), myalgia and chills (>10%). • The most frequent adverse reactions in clinical trial participants 12 to 15 yrs of age were injection site pain (> 90%), fatigue and headache (> 70%), myalgia and chills (> 40%), arthralgia and pyrexia (> 20%). There is limited experience with use of COMIRNATY® in pregnant women. Administration of COMIRNATY® in pregnancy should only be considered when the potential benefits outweigh any potential risks for the mother and fetus. It is unknown whether COMIRNATY® is excreted in human milk. ● ● . . · Interactions with other medicinal products or concomitant administration of COMIRNATYⓇ with other vaccines has not been studied. For complete information on the safety of COMIRNATY® always make reference to the approved Summary of Product Characteristics and Package Leaflet available in all the languages of the European Union on the EMA website. The black equilateral triangle ▼ denotes that additional monitoring is required to capture any adverse reactions. This will allow quick identification of new safety information. Individuals can help by reporting any side effects they may get. Side effects can be reported to EudraVigilance or directly to BioNTech using email [email protected], telephone +49 6131 9084 0, or via the website www.biontech.de BIONTECH#4Safety Information AUTHORIZED USE IN THE U.S. COMIRNATY® (COVID-19 Vaccine, mRNA) is an FDA-approved COVID-19 vaccine for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals 12 yrs of age and older. It is also authorized under EUA to provide a 3-dose primary series to individuals 6 months through 4 yrs of age, 2-dose primary series to individuals 5 yrs of age and older, a third primary series dose to individuals 5 yrs of age and older who have been determined to have certain kinds of immunocompromise, a single booster dose to individuals 5 through 11 yrs of age and older who have completed a primary series with Pfizer-BioNTech COVID-19 Vaccine or COMIRNATYⓇ, a third primary series dose to individuals 12 years of age and older with certain kinds of immunocompromise, a first booster dose to individuals 12 years of age and older who have completed a primary series with Pfizer-BioNTech COVID-19 Vaccine or COMIRNATY®, a first booster dose to individuals 18 yrs of age and older who have completed primary vaccination with a different authorized COVID-19 vaccine, a second booster dose to individuals 50 yrs of age and older who have received a first booster dose of any authorized COVID-19 vaccine; and a second booster dose to individuals 12 yrs of age and older who have been determined to have certain kinds of immunocompromise and who have received a first booster dose of any authorized COVID-19 vaccine. The booster schedule is based on the labeling information of the vaccine used for the primary series. IMPORTANT SAFETY INFORMATION Individuals should not get the vaccine if they: had a severe allergic reaction after a previous dose of this vaccine • had a severe allergic reaction to any ingredient of this vaccine Individuals should tell the vaccination provider about all of their medical conditions, including if they: have any allergies have had myocarditis (inflammation of the heart muscle) or pericarditis (inflammation of the lining outside the heart) • have a fever . 4 ● ● ● ● have a bleeding disorder or are on a blood thinner are immunocompromised or are on a medicine that affects the immune system are pregnant, plan to become pregnant, or are breastfeeding have received another COVID-19 vaccine have ever fainted in association with an injection The vaccine may not protect everyone. Side effects reported with the vaccine include: • There is a remote chance that the vaccine could cause a severe allergic reaction o A severe allergic reaction would usually occur within a few minutes to 1 hour after getting a dose of the vaccine. For this reason, vaccination providers may ask individuals to stay at the place where they received the vaccine for monitoring after vaccination Signs of a severe allergic reaction can include difficulty breathing, swelling of the face and throat, a fast heartbeat, a bad rash all over the body, dizziness, and weakness If an individual experiences a severe allergic reaction, they should call 9-1-1 or go to the nearest hospital o O BIONTECH#5Safety Information Myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart) have occurred in some people who have received the vaccine, more commonly in males under 40 yrs of age than among females and older males. In most of these people, symptoms began within a few days following receipt of the second dose of the vaccine. The chance of having this occur is very low. Individuals should seek medical attention right away if they have any of the following symptoms after receiving the vaccine: O chest pain O shortness of breath o feelings of having a fast-beating, fluttering, or pounding heart 01 Additional side effects that have been reported with the vaccine include: O severe allergic reactions; non-severe allergic reactions such as injection site pain; tiredness; headache; muscle pain; chills; joint pain; fever; injection site swelling; injection site redness; nausea; feeling unwell; swollen lymph nodes (lymphadenopathy); decreased appetite; diarrhea; vomiting; arm pain; and fainting in association with injection of the vaccine Data on administration of this vaccine at the same time as other vaccines have not yet been submitted to FDA. Individuals considering receiving this vaccine with other vaccines should discuss their options with their healthcare provider. 5 These may not be all the possible side effects of the vaccine. Serious and unexpected side effects may occur. The possible side effects of the vaccine are still being studied in clinical trials. Call the vaccination provider or health care provider about bothersome side effects or side effects that do not go away Patients should always ask their healthcare providers for medical advice about adverse events. Individuals are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Visit https://www.vaers.hhs.gov or call 1-800-822-7967. In addition, side effects can be reported to Pfizer Inc. at www.pfizersafety reporting. com or by calling 1-800-438-1985. BIONTECH#66 Agenda 01 2nd Quarter 2022 Highlights Ugur Sahin, CEO 02 Pipeline Update Özlem Türeci, CMO 03 Financial Results Jens Holstein, CFO 04 Corporate Outlook Ryan Richardson, Chief Strategy Officer BIONTECH#7Advancing Toward Our Vision 1 marketed vaccine Market leader in COVID-19 vaccines 18 programs in 23 clinical trials 5 randomized Phase 2 trials 7 Oncology 1 Phase 1 program 10+ preclinical programs, 4 FIH trials to start Infectious diseases Driving transformation today Next-gen or variant adapted COVID-19 vaccines Multiple product launches in next 3-5 yrs 5-10 IND submissions per year Mid-term goals Maintain and deepen COVID-19 vaccine leadership Approved products across various disease areas Immunotherapy powerhouse expanding into multiple therapeutic areas Long-term vision BIONTECH#8Highlights in Q2: Corporate & Oncology Pipeline 8 Corporate Updates Oncology: Pipeline Advancement ● ● ● Reported Q2 total revenues of €3.2 bn¹ and year-to-date revenues of €9.6 bn¹ Began construction of first BioN Tainer mRNA vaccine manufacturing facility in Africal Signed new equal share cost/profit collaboration agreement with Genmab for joint development of an antibody targeting CD27 BNT122 (iNeST): Positive data from Phase 1 trial in patients with resected pancreatic cancer showing favorable safety profile and encouraging signs of clinical activity² BNT116 (Fix Vac): FPD in Phase 1 trial in advanced NSCLC BNT142 (RiboMab): FPD in Phase 1/2 trial in CLDN6 positive solid tumors. BNT211 (CLDN6 CAR-T cell therapy): EMA Priority Medicines (PRIME) designation for 3rd or later-line treatment of testicular cancer 1 BioNTech's profit share is estimated based on preliminary data shared between Pfizer and BioNTech as further described in the Annual Report on Form 20-F for the year ended December 31, 2021 as well as the Quarterly Report as of and for the three and six months ended June 30, 2022, filed as an exhibit to BioNTech's Current Report on Form 6-K filed on August 8,2022. Any changes in the estimated share of the collaboration partner's gross profit will be recognized prospectively. 2 Investigator-initiated trial BIONTECH#9Highlights in Q2: COVID-19 Vaccine / COMIRNATY 9 Broad label across age groups Strong global distribution da Variant adapted & next-gen vaccines ● FDA granted EUA for primary series in children 6 months through 4 yrs of age and for booster dose in children 5 through 11 yrs of age Pediatric label now includes ¹: 6 mo. to <5 yrs (3 µg) 5 yrs to <12 yrs (10 µg) 12 yrs + (30 µg) ● ● ● More than 3.6 bn doses delivered to 180 countries and territories since launch Dec. 2020² Order book 2022: ~2.5 bn doses² New agreement with U.S. government to provide additional 105m doses of COVID-19 vaccine with option for another 195m doses Fostering global health equity: On track to deliver a total of 2 bn doses to low- and middle-income countries by end of 2022 ● Variant adapted vaccines: Omicron BA.1 adapted vaccine candidates demonstrated high immunogenicity and tolerable safety profile Regulatory submissions of Omicron BA.1- and BA.4/5-adapted bivalent vaccines are ongoing worldwide Next-gen vaccines: ● ● ● Initiated Phase 2 trial of BNT162b5: bivalent vaccine candidate based on enhanced versions of SARS-CoV-2 ancestral strain and Omicron BA.2 variant spike proteins engineered for broader immunity 1 Approved as a 2-dose series for prevention of COVID-19 in individuals 12 yrs of age and older; 2-dose series under Emergency Use Authorization for individuals 5-11 yrs old, and 3-dose series under emergency use authorization for children 6 months through 4 yrs of age 2 As of beginning of July 2022 BIONTECH#10SARS-CoV-2 Epidemiology Changes Quickly: Vaccine Updates Need Timely Adaptation With the Pace of Virus 100 Proportion of Strains Omicron BA.1 Omicron BA.2 Omicron BA.2.12.1 BOOS Omicron BA.4 Omicron BA.5 75 50 25 0 Delta Dec 2021 Pre-clinical/CMC (proposed) Feb 2022 Clinical (current) ~8 months Sampling Date ~3 months Omicron Wave Circulating Strains Apr 2022 10 CMC, chemistry, manufacturing and controls GISAID Initiative database: https://www.gisaid.org/ (accessed June 20, 2022). USA Jun 2022 SARS-CoV-2 virus continues to evolve: Currently seeing new variant waves every ~3 months Variant vaccine adaptation timelines BIONTECH#11Preparing for Launch of Omicron-Adapted Bivalent Vaccines in Early October 2022 11 Regulatory Engagement Clinical Development loc CO ЮСП 00 Manufacturing Scale-Up FDA, EMA and other regulators recommended Omicron-adapted bivalent vaccines Submissions ongoing worldwide for both BA.1- and BA.4/5-adapted bivalent vaccines ● • FDA: Provided guidance for bivalent vaccine encoding Omicron BA.4/5 spike protein ● ● ● ● EMA: Omicron BA.1-adapted bivalent vaccine submission finalized; preparing submission of preclinical and CMC data package for Omicron BA.4/5-adapted bivalent vaccine Clinical trial of Omicron BA.4/5-adapated bivalent vaccine expected to initiate in August BA.1- and BA.4/5-adapted bivalent vaccines manufacturing initiated Planning to supply both vaccines in time for fall booster campaign CMC, chemistry, manufacturing, and controls Planned Launch First shipments expected as early as October subject to regulatory approval BIONTECH#1212 Agenda 01 2nd Quarter 2022 Highlights Ugur Sahin, CEO 02 Pipeline Update Özlem Türeci, CMO 03 Financial Results Jens Holstein, CFO 04 Corporate Outlook Ryan Richardson, Chief Strategy Officer BIONTECH#13Omicron-BA.1 Adapted Vaccines as 4th Dose Elicit Improved Omicron Neutralization Response FFRNT 50 10,000 1,000 100 10 Participants WITHOUT evidence of infection up to 1 month after first study vaccination >55 yrs old participants, 30 and 60 µg dose 501.1 78.4 OMI 30 µg n=17 822.0 145.3 OMI 60 µg n=18 BA.1 BA.4/5 Internal data. FFRNT, fluorescent foci reduction neutralization test; LOD, limit of detection. GMR, geometric mean ratio 1 GMR superiority criterion: the lower bound of 95% confidence interval for GMR is >1.0 13 2 Non-inferiority criterion: the lower bound of 95% confidence interval for interval for the percentage difference is >-5 3 GMR "super" superiority criterion: the lower bound of 95% confidence interval for GMR is >1.5 771.3 226.3 Bivalent 30 µg n=13 678.1 137.2 Bivalent 60 µg n=18 LOD Superiority¹ for GMR and non-inferiority2 for sero responses (monovalent and bivalent vaccines) "Super" superiority³ for GMR (monovalent vaccines); Neutralization activity against BA.4/5 reduced BIONTECH#14Omicron BA.4/5 RBD and NTD Sequences are distinct From BA.1 and BA.2 14 a BA.1 BA.1.1 BA.3 BA.2 BA.2.13 BA.2.12.1 BA.4/BA.5 NTD NTD T191 L24S del25-27 A67V 169-70 T951 G142D RBD viral membrane ə RBD del143-145 N211 del212 V213G G339D R346K S371L S371F S373P S375F T376A D405N R408S K417N N440K -90° NTD L452M L452Q L452R S477N| T478K E484A Q493R G496S SD1/SD2 Q498R N501Y Y505H T547K D614G H655Y N679K RBD, receptor binding domain; NTD, N-terminal domain Stalls et al., Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell reports, 2022 HR1 P681H S704L N764K D796Y N856K Q954H N969K L981F RBD Omicron-BA.2 unique mutations Omicron-BA.2 common mutations Omicron-BA.1 unique mutations BIONTECH#15Omicron BA.4/5 Monovalent and Bivalent Boosters in Mice Substantially Increase Omicron Neutralization Responses to All Tested Omicron Variants PVN 50 titer (Serum Dilution ¹) 105 104 103 10² 101 014 Compared to Monovalent OMI BA.1, BA.4/5 neutralizing titers increase by 11.3 fold (mono BA.4/5) or ~4.8 fold (bivalent BA.4/5) 0 P 4150 3490 1131 Wildtype BA.1 BA.2 018- 617 436 BA. BA.4/5 2.12.1 OMIBA.1 9870 4150 5869 4935 4935 Wildtype BA.1 BA.2 BA. BA.4/5 2.12.1 OMI BA.4/5 15 N=8 mice Balb/c mice. Mice preim munized with 2 doses of BNT162b2; boosters given at day 104 Pseudovirus neutralization assay; LOD, Limit of Detection; GMT, geometric mean titers 414 5869 2075 2691 3200 2075 Wildtype BA.1 BA.2 BA. BA.4/5 2.12.1 BNT162b2+ OMI BA.4/5 - LOD GMT BIONTECH#16Pursuing Multiple Novel COVID-19 Vaccine Approaches to Provide Durable and High-Level Protection against Evolving Variants 16 Next generation SARS-CoV-2 spike antigen Engineered for optimized immunogenicity Increase prefusion stability Expose more neutralizing-sensitive epitopes ● ● Long-term: Next-Generation Vaccine Approaches T cell enhancing vaccine candidate Designed to stimulate and enhance T cell immunity BNT162b5: bivalent vaccine candidate Enhanced SARS-CoV-2 spike protein of ancestral strain and Omicron BA.2 sublineage Phase 2: FPD in July Clinical trial start expected 2H 2022 Pan-SARS-CoV-2 vaccine candidate Potential for greater, more durable protection to manage future variants of concern Proof-of-concept trial expected 2H 2022 Long-term strategy comprises multipronged approach designing and testing multiple constructs with the aim to engage different arms of the immune system including antibodies and T cells BIONTECH#17Oncology Pipeline: Significant Progress and Expansion in 2022 Drug class Platform mRNA Cell therapies Antibodies SMIM 17 Fix Vac iNeST RiboMabs RiboCytokines Adjuvant pancreatic ductal adenocarcinoma¹ Intratumoral immunotherapy SAR441000 (BNT131)³ Solid tumors (IL-12sc, IL 15-sushi, GM-CSF, IFNa) BNT141 Multiple solid tumors (CLDN 18.2) BNT142 BNT151 Multiple solid tumors (CD3×CLDN6) Multiple solid tumors (optimized IL-2) Multiple solid tumors (IL-7, IL-2) BNT 152, BNT153 BNT211 Multiple solid tumors (CLDN6) BNT212 Pancreatic, other cancers (CLDN 18.2) Multiple solid tumors BNT221 (NEO-PTC-01) To be selected CAR T cells + CARVac Neoantigen-based T cells TCR engineered T cells Next-gen immune checkpoint modulators Product candidate BNT111 BNT112 BNT113 BNT 1151 BNT116 Targeted cancer antibodies Toll-like receptor binding Autogene cevumeran (BNT122)² Indication (targets) Advanced and R/R melanoma Prostate cancer HPV16+ head and neck cancer Ovarian cancer NSCLC 1L melanoma Adjuvant colorectal cancer Solid tumors GEN1046 (BNT311)4 GEN 1042 (BNT312)4 GEN1053 (BNT313)4 BNT321 (MVT-5873) BNT411 All tumors Metastatic NSCLC (PD-L1x4-1BB) Multiple solid tumors (PD-L1x4-1BB) Multiple solid tumors (CD40x4-1BB) Malignant solid tumors (CD27) Pancreatic cancer (sLea) Solid tumors (TLR7) SMIM, small molecule immunomodulators. 1 Investigator-initiated Phase 1 trial; 2 Collaboration with Genentech; 3 Collaboration with Sanofi; 4 Collaboration with Genmab. Pre-clinical Phase 1 Phase 2 Phase 3 [['|'|'||| Milestones FPD in July 2022 Data update: 1H 2023 FPD in Jan. 2022 FPD in July 2022 Data update: 2H 2022 Start Phase 1: 2H 2022 BIONTECH#18Fix Vac I BNT116: Phase 1 Trial in Patients with Advanced NSCLC 18 Advanced or metastatic non-small-cell lung cancer Key endpoints Primary: Safety and tolerability Secondary: Clinical activity NSCLC, non-small-cell lung cancer; TPS, tumor proportion score *Regeneron's LibtayoⓇ Clinicaltrials.gov: NCT05142189. Cohort 1: BNT116 monotherapy Cohort 2: BNT116 + cemiplim ab* After progression on prior PD-1 inhibitor; PD-L1 expression: TPS >50% Cohort 3: BNT116 + docetaxel After prior platinum-based therapy and PD-1 inhibitor (if eligible) Cohort 4: BNT116 + cemiplim ab* Patients not eligible for chemotherapy; PD-L1 expression: TPS ≥1% Status FPD in July 2022 BIONTECH#19RiboMabs: Nucleoside-modified mRNA Encoding Variable Antibody Formats for in vivo Translation In vivo translation and systemic availability of active drug at therapeutically relevant plasma concentrations mRNA backbone designed for minimal immunogenicity Encoded antibodies target tumor-associated antigens Sustained in vivo production may result in prolonged serum half-life ● ● Shared LNP formulation across platform candidates Liver-targeting LNP formulation for intravenous delivery Encouraging preclinical data ¹ ● nature medicine Elimination of large tumors in mice by mRNA-encoded bispecific antibodies Christiane R Stadler', Hayat Bähr-Mahmud¹, Leyla Celik', Bernhard Hebich¹5, Alexandra S Roth¹5, René P Roth ¹,5, Katalin Karikó¹, Özlem Türeci² & Ugur Sahin¹,3,4 Median tumor volume (mm) 1,500- 1,000- 500- 0 10 20 30 40 50 Days after tumor inoculation CD3 x CLDN6 mRNA rCD3 x CLDN6 protein Luc mRNA Vehicle control Antibody-encoding mRNA (drug substance) 5 UTR CDS 1 CDS 2 Ommy+ BNT141 3 UTR Product Candidate BNT142 IgG, immunoglobulin G; LNP, lipid nanoparticles; TAA; CLDN18.2, Claudin-18.2; CD3 cluster of differentiation 3 (protein complex); CLDN, Claudin 1 Stadler, C.R. et al. Nature Medicine 2017 https://www.nature.com/articles/nm.4356 19 m14 Lipids PEG-lipid Helper lipid Cationic lipid Indication (Targets) Solid Tumors (CLDN 18.2) Solid Tumors (CD3+CLDN6) mRNA/LNP (drug product) 60-120 nm Antibody- encoding mRNA In vivo translation to drug Pre-clinical Phase 1 IgG (1) Intravenous injection (2) LNP target site: liver (3) Translation and systemic availability of active drug Phase 2 BIONTECH#20iNeST I Autogene Cevumeran (BNT122) Phase 1 for Adjuvant Treatment of Pancreatic Cancer 20 Vaccine-induced Neoantigen-specific immune responses of high magnitude against at least one of the neoantigens by ex vivo IFNY ELISPOT in half of the patients. Prolonged Relapse free survival in patients who have high magnitude Immune responses. Number of neoantigens in autogene cevumeran 20 15- 0 Responders (n=8) Non-responders (n=8) iNeST is being developed in collaboration with Genentech. RFS, recurrence-free survival Immunogenic Non-immunogenic No data Balachandran VP, et al. ASCO Annual Meeting 2022; Poster presentation 2516. Investor-initiated single-center study sponsored by Memorial Sloan Kettering Cancer Center IFNy spots x 10 cells 1000 100 10 0 Responders (n=8) 0 * 20 40 60 80 Weeks after surgery *Patient treated in non-protocol-specified sequence 100 100 RFS (%) 50 O No. at risk 8 Responder Non-responder 8 00 00 IL Median RFS: Not reached Median RFS: 13.7 months T 12 18 24 Time (months) (O 6 8 COCO 6 7 5 62 ON 2 RFS from resection (n=16) 1 30 00 BIONTECH#21Expanding Strategic Collaboration With Genmab GEN 1046 / BNT3111 Anti- PD-L1 орга Anti- 4-1BB Phase 2: R/R NSCLC Phase 1/2: Advanced solid tumors Bispecific antibody: Conditional 4-1 BB co-stimulation while blocking PD-(L)1 axis GEN 1042/BNT312¹ 21 1 Collaboration with Genmab based on 50/50 sharing of costs and profits 2 HexaBody® technology owned by Genmab Anti- CD40 Anti- 4-1BB RO Phase 1/2: Advanced solid tumors Bispecific antibody: Combines targeting and conditional activation of CD40 and 4-1BB on immune cells GEN1053/BNT3131 Phase 1/2: Solid tumors FPD expected in 2H 2022 Anti- CD27 Monospecific HexaBody2 targeting CD27 on naïve and activated T cells Next-generation immunomodulators designed to prime and activate anti-tumor T cell and Natural Killer cell function BIONTECH#2222 Agenda 01 2nd Quarter 2022 Highlights Ugur CEO 02 03 Financial Results Jens Holstein, CFO Update Özlem Türeci, CMO 04 Corporate Outlook Ryan Richardson, Chief Strategy Officer BIONTECH#23Key Highlights for Q2 2022 23 Total Revenues ¹ €3.2 bn Diluted EPS A €6.45 Operating Result Ⓡ €2.2 bn Cash and Trade Receivables €9.3 bn + €10.4 bn 1 BioNTech's profit share is estimated based on preliminary data shared between Pfizer and BioNTech as further described in the Annual Report on Form 20-F for the year ended December 31, 2021 as well as the Quarterly Report as of and for the three and six months ended June 30, 2022, filed as an exhibit to BioNTech's Current Report on Form 6-K filed on August 8, 2022. Any changes in the estimated share of the collaboration partner's gross profit will be recognized prospectively. BIONTECH#24Q2 and H1 2022 COVID-19 Vaccine Revenues 24 €3.2 bn €2.0 bn €0.6 bn €0.6 bn Q2 2022 €9.5 bn €6.6 bn €1.7 bn €1.2 bn H1 2022 Share of gross profit from COVID-19 vaccine sales in the Pfizer and Fosun Pharma territory (100% gross margin) Direct COVID-19 vaccine sales to customers in BioNTech's territory COVID-19 vaccine sales to collaboration partners of products manufactured by BioNTech Q2 2022 revenues in line with our expectations 1 BioNTech's profit share is estimated based on preliminary data shared between Pfizer and BioNTech as further described in the Annual Report on Form 20-F for the year ended December 31, 2021 as well as the Quarterly Report as of and for the three and six months ended June 30, 2022, filed as an exhibit to BioNTech's Current Report on Form 6-K filed on August 8, 2022. Any changes in the estimated share of the collaboration partner's gross profit will be recognized prospectively. BIONTECH#25Q2 and H1 2022 Financial Results - Profit or Loss Three months ended June 30, (in millions, except per share data)¹ Commercial revenues² Research & development revenues Total revenues Cost of sales Research and development expenses Sales and marketing expenses General and administrative expenses Other operating income less expenses Operating income Finance income less expenses Income taxes Profit for the period Earnings per share Basic profit for the period per share Diluted profit for the period per share 2022 €3,166.3 30.2 €3,196.5 (764.6) (399.6) (17.8) (130.0) 325.1 €2,209.6 109.7 (647.3) €1,672.0 €6.86 €6.45 2021 €5,280.5 28.0 €5,308.5 (883.8) (201.1) (13.3) (47.8) 35.9 €4,198.4 (175.6) (1,235.6) €2,787.2 €11.42 €10.77 Six months ended June 30, 2022 €9,528.5 42.6 €9,571.1 (2,058.7) (685.4) (32.1) (220.8) 388.2 €6,962.3 375.1 (1,966.6) €5,370.8 €22.00 €20.69 1 Numbers have been rounded, numbers presented may not add up precisely to the totals and may have been adjusted in the table context. Presentation of the consolidated statements of profit or loss has been condensed. 25 2 BioNTech's profit share is estimated based on preliminary data shared between Pfizer and BioNTech as further described in the Annual Report on Form 20-F for the year ended December 31, 2021 as well as the Quarterly Report as of and for the three and six months ended June 30, 2022, filed as an exhibit to BioNTech's Current Report on Form 6-K filed on August 8, 2022. Any changes in the estimated share of the collaboration partner's gross profit will be recognized prospectively. 2021 €7,308.0 48.9 €7,356.9 (1,116.9) (417.3) (22.0) (86.7) 146.6 €5,860.6 (195.5) (1,749.8) €3,915.3 €16.07 €15.14 BIONTECH#262022 Financial Year Guidance Reiterated COVID-19 Vaccine Revenues for FY 20221 Estimated BioN Tech COVID-19 vaccine revenues Planned FY 2022 Expenses and Capex¹ R&D expenses SG&A expenses Capital expenditure Estimated FY 2022 Tax Assumptions BioN Tech Group estimated annual effective income tax rate € 13-17 bn € 1,400 1,500 m € 450-550 m € 450-550 m -28%² 26 1 Ranges reflect current base case projections and do not include potential effects caused by or driven from additional collaborations or potential M&A transactions. 2 BioNTech Group estimated annual effective income tax rate decreased from 31.6% (FY 2021) to -28% (FY 2022) due to decreasing average trade tax rates. BIONTECH#2727 Agenda 01 2nd Quarter 2022 Highlights Ugur 02 03 Financial Results Jens Holstein, CFO Update Özlem Türeci, CMO 04 Corporate Outlook Ryan Richardson, Chief Strategy Officer BIONTECH#28Strong Position and Outlook for Global COVID-19 Vaccine Franchise 28 >3.6 bn doses shipped to 180 countries or territories since product launch¹ Increasing market share since January 2022² All markets 3³: increase from 52% to 63% Developed markets 4: increase from 59% to 68% ● 2022 order book: -2.5 bn doses ● U.S. government ordered additional 105 m doses with value of $3.2 bn Option for another 195 m doses • EC order of 650 m doses for delivery in 2022 • Amended contract for rephasing deliveries toward Q4 2022 ● ● Shipment volumes expected to increase with planned launch of Omicron variant-adapted vaccines in the late fall5 1 As of beginning of July 2022 2 Cumulative Share of Doses from January 1, 2022 to July 20, 2022 in markets in which Pfizer and BioNTech operate and that report market share data 3 Incl. all markets in Developed Markets (4) plus Emerging Markets (Argentina, Chile, Ecuador, Hong Kong, Nepal, Peru, South Africa, Uruguay) 4 Includes the U.S., EU/EEA, other Int'l Developed markets (Japan, South Korea, Switzerland, Ukraine) 5 Starting date of January 1, 2022 for this data set is from Q1 2022 earnings presentation 5 Pending regulatory approval Distribution of COVID-10 vaccine in collaboration with Pfizer BIONTECH#29Delivering on Commitment to Provide Equitable Access to Medicines 29 BioNTainer Launch in Africa ● ● ● >1.5 bn COVID-19 vaccine doses shipped to low-and-middle income countries of 2 bn doses pledged ¹ ● End-to-end mRNA production units with capacity of up to >50 million doses/year First manufacturing facility to become a node in decentralized and robust African end-to-end manufacturing network Construction of facility underway following groundbreaking in Rwanda Potential additional sites for Senegal and South Africa 1 Between Dec 2020 and Jul 17, 2022 via bi-lateral and donation agreements Potential Manufacturing Sites in Africa Senegal, Rwanda, & South Africa Groundbreaking for Rwanda in June 2022 BIONTECH#30Selected 2022 Pipeline Milestones COVID-19 vaccine: Follow on and Next Gen Vaccines 4 Infectious Disease First-In-Human Trial Starts 4 Oncology First-in- Human Trial Starts 30 3 Data Updates Milestones Omicron BA.4/5-adapted bivalent vaccine trial start BNT162b5: Next-generation bivalent vaccine, enhanced SARS-CoV-2 encoding ancestral and BA.2 spike antigen T cell enhancing vaccine trial start Additional next-generation vaccine trial starts, including pan-SARS-CoV-2 vaccine Multiple data updates Shingles vaccine ¹ BNT163 HSV2 vaccine BNT164 tuberculosis vaccine² BNT 165 malaria vaccine BNT141 RiboMab in solid tumors (CLDN18.2) BNT142 RiboMab in solid tumors (CD3×CLDN6) BNT116 FixVac in combo with Cemiplimab in NSCLC BNT313 (GEN1053) in solid tumors³ BNT 161 influenza mRNA vaccine ¹ BNT1224 Phase 2 iNeST in combo with Pembro in frontline melanoma BNT211 Phase 1/2 CAR-T/CLDN6+ in multiple solid tumors HSV 2, Herpes simplex virus type 2; FPD, first patient dosed; CLDN, Claudin; NSCLC, non-small cell lung cancer 1 Partnered with Pfizer; 2 Collaboration with BMGF; 3 Collaboration with Genmab 4 Partnered with Genentech Anticipated Timing August 2022 Phase 2: FPD July 2022 2H 2022 2H 2022 2H 2022 2H 2022 2H 2022 2H 2022 / early 2023 2H 2022 / early 2023 FPD in Jan. 2022 FPD in July 2022 FPD in July 2022 2H 2022 July 2022 now in 1H 2023 2H 2022 BIONTECH#31Outlook 2022 and Beyond 31 Once in a generation opportunity to transform medicine Further development of COVID-19 vaccine ☆ Accelerate late- stage oncology programs Advance infectious disease portfolio RA KY Pursue complementary acquisitions Transform & expand global organization Bring long-term value to patients, shareholders and society BIONTECH#3232 THANK YOU BIONTECH