#1Q3 2022 Earnings Call October 26, 2022 © 2022. All rights reserved. IQVIA® is a registered trademark of IQVIA Inc. in the United States, the European Union, and various other countries. IQVIA#2Legal This presentation should be viewed in conjunction with IQVIA's Q3 2022 earnings call Safe Harbor Statement for Forward-Looking Statements This presentation contains "forward-looking statements" within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including, without limitation, our fourth-quarter and full-year 2022 guidance. In this context, forward-looking statements often address expected future business and financial performance and financial condition, and often contain words such as "expect," "assume," "anticipate," "intend," "plan," "forecast," "believe," "seek," "see," "will," "would," "target," similar expressions, and variations or negatives of these words that are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from our expectations due to a number of factors, including, but not limited to, the following: business disruptions caused by natural disasters, pandemics such as the COVID-19 (coronavirus) outbreak, including any variants, and the public health policy responses to the outbreak, international conflicts or other disruptions outside of our control such as the current situation in Ukraine and Russia; our ability to accurately model or forecast the impact of the spread and/or containment of COVID-19, including any variants, among other sources of business interruption, on our operations and financial results; most of our contracts may be terminated on short notice, and we may lose or experience delays with large client contracts or be unable to enter into new contracts; the market for our services may not grow as we expect; we may be unable to successfully develop and market new services or enter new markets; imposition of restrictions on our use of data by data suppliers or their refusal to license data to us; any failure by us to comply with contractual, regulatory or ethical requirements under our contracts, including current or future changes to data protection and privacy laws; breaches or misuse of our or our outsourcing partners' security or communications systems; failure to meet our productivity or business transformation objectives; failure to successfully invest in growth opportunities; our ability to protect our intellectual property rights and our susceptibility to claims by others that we are infringing on their intellectual property rights; the expiration or inability to acquire third party licenses for technology or intellectual property; any failure by us to accurately and timely price and formulate cost estimates for contracts, or to document change orders; hardware and software failures, delays in the operation of our computer and communications systems or the failure to implement system enhancements; the rate at which our backlog converts to revenue; our ability to acquire, develop and implement technology necessary for our business; consolidation in the industries in which our clients operate; risks related to client or therapeutic concentration; government regulators or our customers may limit the number or scope of indications for medicines and treatments or withdraw products from the market, and government regulators may impose new regulatory requirements or may adopt new regulations affecting the biopharmaceutical industry; the risks associated with operating on a global basis, including currency or exchange rate fluctuations and legal compliance, including anti-corruption laws; risks related to changes in accounting standards; general economic conditions in the markets in which we operate, including financial market conditions, inflation, and risks related to sales to government entities; the impact of changes in tax laws and regulations; and our ability to successfully integrate, and achieve expected benefits from, our acquired businesses. For a further discussion of the risks relating to our business, see the "Risk Factors" in our annual report on Form 10-K for the fiscal year ended December 31, 2021, filed with the Securities and Exchange Commission (the "SEC"), as such factors may be amended or updated from time to time in our subsequent periodic and other filings with the SEC, which are accessible on the SEC's website at www.sec.gov. These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in this presentation and in our filings with the SEC. We assume no obligation to update any such forward-looking statement after the date of this presentation, whether as a result of new information, future developments or otherwise. Past Performance In all cases where historical results are presented or past performance is described, we note that past performance is not a reliable indicator of future results and performance. Trademarks All trademarks or service marks are the property of IQVIA or their respective owners. Solely for convenience, the trademarks, service marks and trade names are referenced without the Ⓡ, (SM) and (TM) symbols, but we will assert, to the fullest extent under applicable law, our rights or the rights of the applicable licensors to these marks. IQVIA 1#3Legal Non-GAAP Information This presentation includes information based on financial measures that are not recognized under generally accepted accounting principles in the United States ("GAAP"), such as Adjusted EBITDA, Adjusted Net Income, Adjusted Diluted Earnings per Share, and Free Cash Flow. Non-GAAP financial measures are presented only as a supplement to the company's financial statements based on GAAP. Non-GAAP financial information is provided to enhance understanding of the company's financial performance, but none of these non-GAAP financial measures are recognized terms under GAAP, and non-GAAP measures should not be considered in isolation from, or as a substitute analysis for, the company's results of operations as determined in accordance with GAAP. The company uses non-GAAP measures in its operational and financial decision making and believes that it is useful to exclude certain items in order to focus on what it regards to be a more meaningful indicator of the underlying operating performance of the business. For example, the Company excludes all the amortization of intangible assets associated with acquired customer relationships and backlog, databases, non-compete agreements and trademarks, trade names and other from non-GAAP expense and income measures as such amounts can be significantly impacted by the timing and size of acquisitions. Although we exclude amortization of acquired intangible assets from our non-GAAP expenses, we believe that it is important for investors to understand that revenue generated from such intangibles is included within revenue in determining net income attributable to IQVIA Holdings Inc. As a result, internal management reports feature non-GAAP measures and are used to prepare strategic plans and annual budgets and review management compensation. The company also believes that investors may find non-GAAP financial measures useful for the same reasons, although investors are cautioned that non-GAAP financial measures are not a substitute for GAAP disclosures. The non-GAAP financial measures are not presented in accordance with GAAP. Please refer to the appendix of this presentation for reconciliations of non-GAAP financial measures contained herein to the most directly comparable GAAP measures. Our fourth-quarter and full-year 2022 guidance measures (other than revenue) are provided on a non-GAAP basis without a reconciliation to the most directly comparable GAAP measure because the company is unable to predict with a reasonable degree of certainty certain items contained in the GAAP measures without unreasonable efforts. Such items include, but are not limited to, acquisition related expenses, restructuring and related expenses, stock-based compensation and other items not reflective of the company's ongoing operations. Non-GAAP measures are frequently used by securities analysts, investors and other interested parties in their evaluation of companies comparable to the company, many of which present non-GAAP measures when reporting their results. Non-GAAP measures have limitations as an analytical tool. They are not presentations made in accordance with GAAP, are not measures of financial condition or liquidity and should not be considered as an alternative to profit or loss for the period determined in accordance with GAAP or operating cash flows determined in accordance with GAAP. Non-GAAP measures are not necessarily comparable to similarly titled measures used by other companies. As a result, you should not consider such performance measures in isolation from, or as a substitute analysis for, the company's results of operations as determined in accordance with GAAP. IQVIA 2#43rd Quarter Results $M, except per share data Revenue 5.0% AFx $3,562 Q3 2022 10.5% CFx Adjusted EBITDA(1) 11.8% AFX Adjusted Diluted EPS(1) 14.3% AFx $814 $3,391 Q3 2021 Dollars are at actual foreign exchange rates. AFx is actual currency. CFx is constant currency. (1) See reconciliation of non-GAAP items in the Appendix. $2.48 $728 $2.17 Q3 2022 Q3 2021 Q3 2022 Q3 2021 IQVIA 3#53rd Quarter and Year-to-Date Revenue $M Q3 YTD VPY% VPY% VPY% VPY% 2022 2021 2022 2021 AFx CFx AFx CFx Technology & Analytics $1,400 $1,337 4.7% 11.6% $4,247 $4,038 5.2% 10.3% Solutions Research & $1,979 $1,853 6.8% 10.7% $5,863 $5,612 4.5% 7.1% Development Solutions Contract Sales & $183 $201 (9.0%) 1.0% $561 $588 (4.6%) 2.9% Medical Solutions Revenue $3,562 $3,391 5.0% 10.5% $10,671 $10,238 4.2% 8.1% Dollars are at actual foreign exchange rates. AFx is actual currency, CFx is constant currency.#63rd Quarter and Year-to-Date Profit $M, except per share data Q3 YTD 2022 2021 2022 2021 Adjusted EBITDA (1) $814 $728 $2,426 $2,194 Net Income $283 $261 $864 $648 Diluted Earnings per Share $1.49 $1.34 $4.52 $3.32 Adjusted Net Income (1) $470 $423 $1,413 $1,264 Adjusted Diluted Earnings per Share (1) $2.48 $2.17 $7.39 $6.48 Dollars are at actual foreign exchange rates. (1) See reconciliations of non-GAAP items in appendix.#7R&D Solutions Backlog and NTM Revenue $B Backlog +5.4% AFX +9.4% CFX $25.8 $24.4 Q3 2021 Dollars are at actual foreign exchange rates. AFx is actual currency. CFx is constant currency. NTM: Next Twelve Months Next Twelve Months Revenue $6.9 +2.8% AFX +6.7% CFx $7.1 Q3 2022 Q3 2021 Q3 2022 IQVIA 6#83rd Quarter Balance Sheet and Cash Flow Items and Metrics $M Dollars are at actual foreign exchange rates. Cash & Cash Equivalents Gross Debt Net Debt $1,274 $12,394 $11,120 Gross Leverage Ratio (1) 3.81x Net Leverage Ratio (1) 3.42x Net Cash Provided by Operating Activities $863 Capital Expenditures $165 Free Cash Flow (2) $698 (1) Calculated using last twelve months Adjusted EBITDA. (2) See reconciliation of non-GAAP items in the Appendix. IQVIA 7#9Full-Year 2022 Guidance $M, except per share data Updated Guidance Prior Guidance Revenue $14,325 $14,425 $14,400 $14,550 VPY% CFX (1) 7.4% - 8.2% 7.4% -8.5% VPY% 3.2% -4.0% 3.8% -4.9% Adjusted EBITDA - $3,330 $3,360 $3,345 $3,395 - VPY% - 10.2% 11.2% - 10.7% 12.3% Adjusted Diluted EPS $10.10 $10.20 - - $10.00 $10.20 VPY% - 11.8% 13.0% 10.7% 13.0% - (1) Assumes 2022 foreign currency exchange rates consistent with 2021. All financial guidance assumes October 24, 2022 foreign exchange rates remain in effect for the forecast period. IQVIA 8#10Q4 2022 Guidance $M, except per share data Revenue Guidance $3,654 $3,754 - VPY% CFX (1) 5.5% - 8.2% 0.5% -3.2% VPY% Adjusted EBITDA $904 - $934 VPY% 9.2% - 12.8% Adjusted Diluted EPS VPY% $2.72 - $2.82 6.7% 10.6% - (1) Assumes 2022 foreign currency exchange rates consistent with 2021. All financial guidance assumes October 24, 2022 foreign exchange rates remain in effect for the forecast period. IQVIA 9#11Q&A IQVIA 10#12Net Income to Adjusted EBITDA Reconciliation Three Months Ended September 30, Nine Months Ended September 30, (in millions) 2022 2021 2022 2021 Net Income Attributable to IQVIA Holdings Inc. $ 283 $ 261 $ 864 $ 648 Provision for income taxes 70 12 212 104 Depreciation and amortization 248 336 773 1,002 Interest expense, net 104 90 281 281 Loss (income) in unconsolidated affiliates 7 12 (5) Income from non-controlling interests 5 Deferred revenue purchase accounting adjustments 1 Stock-based compensation 61 48 136 Other expense (income), net 13 (55) 351 128 51 (93) Loss on extinguishment of debt 1 25 Restructuring and related expenses 16 13 47 44 Acquisition related expenses Adjusted EBITDA 12 22 49 55 $ 814 $ 728 $ 2,426 $ 2,194 IQVIA 11#13Net Income to Adj. Net Income and Per Share Data Reconciliation Nine Months Ended Three Months Ended September 30, September 30, (in millions, except per share data) Provision for income taxes Purchase accounting amortization (1) Income from non-controlling interests 2022 2021 2022 2021 Net Income Attributable to IQVIA Holdings Inc. 283 $ 261 $ 864 $ 648 70 12 212 104 128 231 414 695 12 (5) Loss (income) in unconsolidated affiliates Deferred revenue purchase accounting adjustments Stock-based compensation 61 Other expense (income), net 13 72 1 48 136 128 (55) 51 (93) Loss on extinguishment of debt 1 25 Restructuring and related expenses 16 13 47 44 Acquisition related expenses 12 22 49 55 Adjusted Pre Tax Income 590 533 $ 1,786 $ 1,606 Adjusted tax expense (120) (110) (373) (333) Income from non-controlling interests (5) Minority interest effect in non-GAAP adjustments (2) (4) Adjusted Net Income $ 470 $ 423 $ 1.413 $ 1,264 Adjusted earnings per share attributable to common stockholders: Basic Diluted 2.52 $ 2.21 $ 7.50 $ 6.60 2.48 $ 2.17 $ 7.39 $ 6.48 Weighted average common shares outstanding: Basic 186.5 191.5 188.3 191.5 Diluted 189.4 195.3 191.3 195.0 (1) Reflects all the amortization of acquired intangible assets. (2) Reflects the portion of Q2 Solutions' after-tax non-GAAP adjustments attributable to the minority interest partner. IQVIA 12#14Operating Cash Flow to Free Cash Flow Reconciliation (in millions) Net Cash provided by Operating Activities Acquisition of property, equipment and software Free Cash Flow Three Months Ended September 30, Nine Months Ended September 30, 2022 2022 $ 863 $ 1,700 (165) (503) 698 $ 1,197 IQVIA 13#15Leverage Ratios (in millions) Gross Debt, net of Unamortized Discount and Debt Issuance Costs, as of September 30, 2022 Net Debt as of September 30, 2022 Adjusted EBITDA for the twelve months ended September 30, 2022 Gross Leverage Ratio (Gross Debt/LTM Adjusted EBITDA) Net Leverage Ratio (Net Debt/LTM Adjusted EBITDA) $ 69 69 $ $ 12,394 11,120 3,254 3.8x 3.4x IQVIA 14