Bionomics Results Presentation Deck
Proof of Mechanism: BNC210 Significantly Reduces Anxiety and Panic Symptoms
BNC210 demonstrated reduction in panic symptoms
as measured with the Panic Symptom Scale
Total # of Panic Symptoms
Panic Symptom Intensity
Phase 1b placebo-controlled study
evaluating BNC210 in acute anxiety in
15 healthy volunteers who experienced
a CCK-4-induced panic attack
ā
6
Subjects assessed after a single
dose of BNC210 as they would be
in an acute SAD trial setting
Proof of Mechanism (PoM) in
demonstrating anxiolytic activity
CCK-4 = Cholecystokinin Tetrapeptide (a peptide that induces anxiety and panic symptoms)
100
Panic Symptom Scale
(% of Placebo)
90
80
70
60
40
30
20
10
0
-37.7%
(p<0.048)
Placebo
Panic Symptom Scale
(% of Placebo)
100
90
80
70
60
50
40
30
20
10
0
BNC210
-52.7%
(p<0.041)
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