Bionomics Results Presentation Deck

Proof of Concept: BNC210 Acute Administration Reduces Anxiety-Related Biomarkers in Generalized Anxiety Disorder Patients 7 Amygdala activation is an imaging surrogate for anxiety BNC210 reduced activation of L & R amygdala caused by viewing fearful faces (L: p=0.011; R: p=0.006) 300 mg Connectivity between the amygdala and Anterior Cingulate Cortex (ACC) is very strong in high anxiety BNC210 reduced connectivity between amygdala and ACC while viewing fearful faces (p=0.012) Contrast estimate 1.0 0.8 0.6 0.4 0.2 0.0 -0.2 Placebo Seed hemisphere Left Right + 300 mg BNC210 300 mg significantly reduced self- reported state anxiety - STAI (p=0.003) BNC210 300 mg and 2000 mg reduced threat avoidance behavior of anxious subjects in the JORT behavioral task 0.5- 0.4- 0.3- 0.2- 0.1- 0.0- Mean Intensity of Defensive Behavior Placebo BNC210 Wise T. et al., Biological Psychiatry 2020 (https://doi.org/10.1016/j.biopsych.2019.12.013); Perkins A. et al., Translational Psychiatry 2021 (https://doi.org/10.1038/s41398-020-01141-5) JORT = Joystick Operated Runway Task P=0.165 Lorazepam P=0.007 300 mg Error Bars + SEM P=0.033 2000 mg Bionomics

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