Bionomics Results Presentation Deck

STAI-State Captures Trends in Prespecified and Post-hoc Analysis and Will be Considered as a Key Endpoint in Late-Stage Trials 21 *Post-hoc analyses Trends and Statistical Significance* for BNC210 in Younger Cohort on STAI Anticipation+Performance^^ FAS Age <=30 -15 -10 -5 Better than Placebo BNC210 225 mg 0 5 -1.89 [-6.20 - 2.42] -3.13 [-7.37 1.11] -2.53 [-6.241.17] -7.24 [-14.33 -0.14] -2.95 [-9.89- 3.99] -5.01 [-10.99-0.98] Worse than Placebo BNC210 675 mg BNC210 Overall 0.388 0.146 0.179 0.046 0.397 0.099 ^ Mixed model for repeated measures (MMRM); ^^ ANCOVA Bionomics 9

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