Bionomics Results Presentation Deck

Primary Outcome Measure Analysis (SUDS) Should be Tailored Based on the Profile of BNC210 Efficacy Profile was Largely Unknown Prior to PREVAIL Readout A from Baseline 14 30 25 20 15 10 -5 -10 -15 Average Change in SUDS 2 Secondary Avg. (A → A₂) 1 3 Primary: Avg. (Po → P5) Post-hoc*: Avg. (A → P5) BL R AO A1 A2 PO P1 P2 P3 P4 P5 R1 R2 R3 *Most clinically relevant endpoint combining 2 phases of increased anxiety AUC = Area Under the Curve A from Baseline 30 25 20 15 10 O -5 -10 -15 BL R 2 I I AUC of Change in SUDS Post-hoc: AUC (A → A₂) I I I 3 A0 A1 A2 Secondary: AUC (P₁ → P5) Post-hoc*: AUC (A → P5) ΡΟ P1 P2 P3 P4 P5 R1 R2 R3 Bionomics

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