Bionomics Results Presentation Deck

Proof of Pharmacology in SAD: Acute BNC210 Administration Demonstrates Activity Across the Phases of the Public Speaking Task BNC210 225 mg and 675 mg achieve similar separation from placebo* Mean Change in SUDS Individual Arms 16 Mean A from Baseline 30 20 -10 -20 EA Anticipation A1 BL R AO A2 PO BNC210 225 mg Performance P1 P2 P3 P4 BNC210 675 mg L P5 Post speech R1 R2 R3 *Post-hoc analysis of mean SUDS values. No models or imputations applied ** Standard error represented Placebo Mean Change in SUDS with Combined Arms Mean A from Baseline 30 20 -10 -20 14 BL R Anticipation A1 AO A2 Performance PO P1 P2 Dose response similarity allows for combination of active arms (225 mg and 675 mg) for further analysis BNC210 Overall J P3 P4 P5 Placebo Post speech R1 R2 R3 Bionomics 2

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