Bionomics Results Presentation Deck

Proof of Target Engagement: BNC210 Modulates a7 Receptors in Healthy Volunteers 5 BNC210 reduces response of nicotinic receptors to stimulation nACHR Nicotinic Acetylcholine Receptor EEG Electroencephalography p-value less than 0.05 p-value less than 0.01 ** BNC210 Reduces Nicotine-induced EEG Responses Power in alpha 2 band 1.5 1.0 0.5 0.0 NS p= 0.3154 Nicotine only (Day - 1) p = 0.0062 ........ 0.5 Nicotine + B N C 2 10 (2000 mg) (Day 7) p=0.0026 1.0 1.5 Nicotine (mg) p=0.0487 2.0 Activation of nicotinic receptors in the brain induces EEG response a7 receptors are the major nACHR populations targeted BNC210 daily oral dosing reduced nicotine-induced EEG in the a2 band M Reduction in EEG response serves to demonstrate BNC210's penetration of blood-brain barrier Bionomics

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