#18 LEGEND BIOTECH November 20, 2023 Third Quarter 2023 Financial Results & Corporate Update This presentation is for investor relations purposes only - Not for product promotional purposes#22 Forward-looking Statements This presentation has been prepared by Legend Biotech Corporation ("Legend Biotech" or the "Company") solely for information purpose and does not contain all relevant information relating to the Company. The safety and efficacy of the agents and/or uses under investigation discussed in this presentation have not been established, except to the extent specifically provided by marketing authorizations previously received from relevant health authorities. Further, for investigational agents and/or uses, the Company cannot guarantee health authority approval or that such agents and/or uses will become commercially available in any country. Certain information contained in this presentation and statements made orally during this presentation relate to or are based on studies, publications, surveys and other data obtained from third- party sources and Legend Biotech's own internal estimates and research. While Legend Biotech believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. While Legend Biotech believes its internal research is reliable, such research has not been verified by any independent source. Statements in this presentation about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, constitute "forward-looking statements" within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements relating to Legend Biotech's strategies and objectives; statements relating to CARVYKTIⓇ, including Legend Biotech's expectations for CARVYKTIⓇ, including manufacturing expectations for CARVYKTI®; and statements about regulatory submissions for CARVYKTI®, and the progress of such submissions with the FDA, the EMA and other regulatory authorities; and expected results and timing of clinical trials; Legend Biotech's expectations for LB2102 and its potential benefits; Legend Biotech's ability to close the licensing transaction with Novartis and potential benefits of the transaction; Legend Biotech's expectations on advancing their pipeline and product portfolio; and the potential benefits of Legend Biotech's product candidates. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors. Legend Biotech's expectations could be affected by, among other things, uncertainties involved in the development of new pharmaceutical products; unexpected clinical trial results, including as a result of additional analysis of existing clinical data or unexpected new clinical data; unexpected regulatory actions or delays, including requests for additional safety and/or efficacy data or analysis of data, or government regulation generally; unexpected delays as a result of actions undertaken, or failures to act, by our third party partners; uncertainties arising from challenges to Legend Biotech's patent or other proprietary intellectual property protection, including the uncertainties involved in the U.S. litigation process; competition in general; government, industry, and general product pricing and other political pressures; the duration and severity of the COVID-19 pandemic and governmental and regulatory measures implemented in response to the evolving situation; as well as the other factors discussed in the "Risk Factors" section of Legend Biotech's Annual Report on Form 20-F filed with the Securities and Exchange Commission (SEC) on March 30, 2023 and Legend Biotech's other filings with the SEC. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described in this presentation as anticipated, believed, estimated or expected. Any forward-looking statements contained in this presentation speak only as of the date of this presentation. Legend Biotech specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. This presentation is for investor relations purposes only - Not for product promotional purposes LEGEND BIOTECH#33 Agenda This presentation is for investor relations purposes only - Not for product promotional purposes 1 2 3 4 LO 5 6 7 Opening Remarks Q3 2023 Performance Overview Latest Pipeline Chart Business Development Deal with Novartis Financial Performance Outlook: 2023 and Beyond Q&A LEGEND BIOTECH#44 Opening Remarks Ying Huang Chief Executive Officer This presentation is for investor relations purposes only - Not for product promotional purposes Lori Macomber Chief Financial Officer LEGEND BIOTECH#55 Q3 2023 Performance CARVYKTIⓇ NET SALES ($MM) U.S. EU Global Q3 2023 Q3 2023 $96 YTD 2023 $206 140 12 152 TOTAL REVENUE ($MM) Q/Q Change 23% 300% 30% Q3 2022 $27 YTD 2022 $89 Y/Y Change 155% N/A 176% Y/Y Change 251% Y/Y Change 130% This presentation is for investor relations purposes only - Not for product promotional purposes EPS ($) Q3 2023 -0.17 YTD 2023 -1.07 Q3 2022 -0.26 YTD 2022 -0.99 Y/Y Change -35% Y/Y Change 8% Q3 2023 and Recent Highlights → Entered into an exclusive, global license agreement with Novartis, which grants Novartis the rights to develop, manufacture and commercialize LB2102 and other potential CAR-T therapies selectively targeting DLL3 a) To receive an upfront payment of $100M and eligible to receive up to $1.01B in milestone payments, as well as tiered royalties on net sales. b) To be reimbursed for development costs for the ongoing Phase 1 clinical trial → 1st patient enrolled for CARTITUDE-6 → One of our Ghent facilities to begin clinical supply manufacturing, pending approvals of the Investigational Medicinal Product Dossier by local authorities → Cash and cash equivalents, time deposits, and short-term inves ments of $1.4 billion; which we believe will fund operating and capital expenditures through 2025 LEGEND BIOTECH#66 Out-licensing Deal with Novartis on CAR-T Therapies Targeting DLL3 Legend announced on Nov 13, 2023 an exclusive, global license agreement with Novartis to advance certain DLL3-targeted CAR-T therapies, including LB2102, an investigational therapy for small cell lung cancer. AN UPFRONT PAYMENT $100M ELIGIBLE MILESTONE PAYMENTS up to POTENTIAL APPLICATION OF T-Charge™ Platform of Novartis FOR MANUFACTURING $1.01B This presentation is for investor relations purposes only - Not for product promotional purposes Plus Tiered Royalties on Net Sales DLL3 DEVELOPMEMT AND COSTS → Legend to conduct Ph1 for LB2102 in the US Novartis to conduct all other development for the licensed products LEGEND BIOTECH#77 Expanding Our Manufacturing Capabilities Bringing cell therapies to market given unique challenges to improve overall supply State-Of-The-Art CARVYKTI Manufacturing Facilities ● ● Obelisc Facility in Ghent, Belgium received license from the Federal Agency for Medicines and Health Products in Belgium for clinical supply manufacturing Awaiting Investigational Medicinal Product Dossier approvals from local authorities Anticipate manufacturing cilta-cel at Ghent for clinical use by the end of the year Janssen In-House Lentivirus Facilities Janssen facility in Switzerland now producing Lentivirus in-house All commercial Lentivirus now produced in-house and we are self-sufficient Additional LV supply is expected to be available from Janssen facilities in US and Netherlands in 2024 an 2025, respectively This presentation is for investor relations purposes only - Not for product promotional purposes Novartis as CMO for Clinical Supply Signed CMO agreement with Novartis during Q2 2023 On track to produce clinical materials in 1H 2024 LEGEND BIOTECH#88 CARVYKTIⓇ Uptake Continues Continued market penetration, population in earlier lines of treatment represents significant opportunity for continued growth 160 140 120 100 80 60 40 20 0 CARVYKTIⓇ Net Product Sales ($MM) U.S. 0 24 55 EU O 55 +176% growth vs Q3'22 70 3 Q2 2022 Q3 2022 Q4 2022 Q1 2023 Q2 2023 114 12 140 Q3 2023 This presentation is for investor relations purposes only - Not for product promotional purposes U.S. ● EU Global YOY Growth 155% N/A 176% QoQ Growth 23% 300% 30% → U.S. QoQ growth of 23% primarily driven by: Ongoing launch Market share expansion Capacity improvements Number of activated U.S. treatment sites increased to 60 EU QOQ growth of 300% primarily due to ongoing launch in Germany LEGEND BIOTECH#99 Our Pipeline PRECLINICAL NSCLC (GPC3) Autologous COLORECTAL (GCC) Autologous SCLC## (DLL3) Autologous NCT05680922 GASTRIC & ESOPHAGEAL & PANCREATIC+ (CLAUDIN 18.2) Autologous NCT05539430 MMT (BCMA) Allogeneic - CAR-18 T NCT05376345 PHASE 1 RRMM (BCMA) LEGEND-2+ Autologous NCT03090659 MMT (BCMA) Allogeneic CAR-NK NCT05498545 HCC+ (GPC3) Autologous NCT05352542 NHL+/ALL+ (CD19 X CD20 X CD22)+ Autologous NCT05318963 NCT05292898 PHASE 2 Global RRMM (BCMA)* CARTIFAN-1 Autologous NCT03758417 RRMM (BCMA)* CARTITUDE-1 Autologous NCT03548207 MM (BCMA)* CARTITUDE-2 Autologous NCT04133636 *In collaboration with Janssen, Pharmaceutical Companies of Johnson & Johnson. *Phase 1 IIT in China. #IND applications have been cleared by the U.S. FDA. #Subject to an exclusive license agreement with Novartis Pharma AG. The safety and efficacy of the agents and/or uses under investigation have not been established. There is no assurance that the agents will receive health authority approval or become commercially available in any country for the uses being investigated. Additionally, as some programs are still confidential, certain candidates may not be included in this list. ALL, acute lymphoblastic leukemia; BCMA, B-cell maturation antigen; DLL3, delta-like ligand 3; GPC3, glypican-3; GCC, guanylyl cyclase C; HCC, hepatocellular carcinoma; IIT, investigator-initiated trial; MM, multiple myeloma; ND, newly diagnosed; NHL, non-Hodgkin lymphoma; NSCLC, non small cell lung cancer; RRMM, relapsed or refractory multiple myeloma; SCLC, small cell lung cancer. This presentation is for investor relations purposes only - Not for product promotional purposes US China PHASE 3 RRMM (BCMA)* 1-3 Prior Lines CARTITUDE-4 Autologous NCT04181827 NDMM (BCMA)* Transplant Not Intended CARTITUDE-5 Autologous NCT04923893 NDMM (BCMA)* Transplant Eligible CARTITUDE-6 Autologous NCT05257083 LEGEND BIOTECH#1010 2023 3Q and YTD Financial Highlights Total Revenue ($MM) 120 100 80 60 40 20 0 250 200 Total Revenue ($MM) 150 100 50 27 0 Q3 2022 89 +251% > YTD 2022 +130% 96 Q3 2023 206 YTD 2023 Net Loss (in $MM) 0 -10 -20 -30 -40 -50 -60 -70 -80 -90 0 Net Loss (in $MM) -50 -100 -150 -200 -250 -300 -350 -400 -85 This presentation is for investor relations purposes only - Not for product promotional purposes Q3 2022 -310 YTD 2022 -27% +20% > -62 Q3 2023 -373 YTD 2023 EPS (in $) 0.00 -0.05 -0.10 -0.15 -0.20 -0.25 -0.30 EPS (in $) 0 -0.2 -0.4 -0.6 -0.8 -1 -1.2 -0.26 Q3 2022 -0.99 YTD 2022 -35% > +8% -0.17 Q3 2023 -1.07 YTD 2023 LEGEND BIOTECH#1111 2023 3Q and YTD Financial Summary ($MM) Cash and Cash Equivalents, Time Deposits, and Short-Term Investments ($MM) License revenue Collaboration revenue Other revenue Total revenue Collaboration cost of revenue Research and development expenses Administrative expenses Selling and distribution expenses LOSS FOR THE PERIOD September 30, 2023 3Q 2023 20 76 0 96 -43 -96 -28 -21 -62 1,428 3Q 2022 0 27 0 27 -25 -105 -23 -19 -85 Y/Y change 178% -69% 251% 71% -8% 21% June 30, 2023 12% -27% This presentation is for investor relations purposes only - Not for product promotional purposes 1,519 YTD 2023 YTD 2022 35 170 0 206 -112 -277 -78 -60 -373 50 39 0 89 March 31, 2023 -42 -255 -54 -68 -310 854 Y/Y change -30% 334% 1% 130% 164% 8% 45% -11% 20% Cash and cash equivalents, time deposits, and short- term investments totaling approximately $1.4B as of September 30, 2023, which we believe will fund operating and capital expenditures through 2025. LEGEND BIOTECH#1212 Focused Investments in Pipeline and Development 160 140 120 100 80 60 40 20 0 147 2022 Q3 Operating Expenses ($MM) -9 R&D delta 7 SG&A delta 145 2023 Q3 This presentation is for investor relations purposes only - Not for product promotional purposes 3Q 2023 OpEx Decreased 1% versus 3Q 2022 The decrease of $8.7 million in R&D expenses was due to: Timing of expenses incurred in connection with the Global Development Plan under the Janssen Agreement. The increase of $2.2 million in S&D Expenses was due to costs associated with the commercialization of CARVYKTIⓇ. The increase of $4.9 million in Administrative Expenses was primarily due to the expansion of administrative functions to facilitate continuous business growth and continued investment in building Legend Biotech's global information technology infrastructure. LEGEND BIOTECH#1313 Outlook: 2023 and Beyond NEAR-TERM GOALS ← ← → ← Increase manufacturing capacity and efficiency Ongoing enrollment of CARTITUDE-5 Ongoing enrollment of CARTITUDE-6 Close the transaction with Novartis Advance pipeline programs First Ghent facility online by end of this year Launch lenalidomide refractory 1-3 prior lines indication based on CARTITUDE-4, if approved by regulatory authorities. The PDUFA target date is April 5, 2024 This presentation is for investor relations purposes only - Not for product promotional purposes LONG-TERM GROWTH STRATEGY → Focus on unmet medical needs in hematology/oncology → Develop therapies with transforming potential → Increase accessibility through lower cost and scalable. manufacturing → Build a global powerhouse by leveraging external collaborations LEGEND BIOTECH#1414 Q&A Ying Huang, Ph.D. Chief Executive Officer Guowei Fang, Ph.D. Chief Scientific Officer & Head of Business Development This presentation is for investor relations purposes only - Not for product promotional purposes Lori Macomber Chief Financial Officer Steve Gavel SVP of Commercial Development, US and Europe LEGEND BIOTECH#1515 This presentation is for investor relations purposes only - Not for product promotional purposes Thank you! LEGEND BIOTECH