#1:: BIOPHARMA The Art of Precision, The Science of Cure Pioneering personalized therapies for oncology and immunology OCTOBER 2023 NASDAQ:IMMX#2Disclaimer: Forward Looking Statements & Market Data ●●● S BIOPHARMA IMMIX This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regarding Immix Biopharma, Inc.'s (the "Company") strategy, future operations, future financial position, projected costs, prospects, plans, and objectives of management, are forward-looking statements. The words "anticipate,” “believe,” “continue,” “could,” “depends,” “estimate,” “expect,” “intend," "may," "ongoing," "plan," "potential,” “predict,” “project," "target," "should,” “will,” “would,” and similar expressions are intended to identify forward- looking statements, although not all forward-looking statements contain these identifying words. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements. In addition, the forward-looking statements included in this presentation represent the Company's views as of the date of this presentation. The Company anticipates that subsequent events and developments will cause its views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date of this presentation. This presentation also includes data from other approved therapies and in trials, which are generated from separate, independent studies and do not come from head- o-head analysis. Differences exist between study or trial designs and subject characteristics, and caution should be exercised when comparing data across studies sourced from publicly available sources. This presentation also contains estimates and other statistical data made by independent parties and by us relating to market size and growth and data about our industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates. In addition, projections, assumptions, and estimates of our future performance and the future performance of the markets in which we operate are necessarily subject to a high degree of uncertainty and risk. These and other factors could cause results to differ materially from those expressed in the estimates made by the independent parties and by us. 2#3IMMIX Biopharma Investment Highlights First CAR-T in AL Amyloidosis 1 100% overall response rate in relapsed/refractory patients Only CAR-T in BCMA-exposed multiple myeloma, a rapidly growing patient segment 2 3 72 NXC-201 CAR-T patients 4 treated across 9 peer- reviewed publications LO 5 First CAR-T Overcoming Neurotoxicity 6 IMX-110 + PD-1 combination promising results in colorectal cancer with 30 patients dosed World-class team ● Overcoming the most feared side-effect of CAR-T, neurotoxicity: No Parkinson's like symptoms ● ● ● ● ● ●●● S 100% overall response rate in relapsed/refractory AL amyloidosis ($3bn market), median 6 prior lines of therapy No drugs approved in relapsed/refractory AL amyloidosis today -50% of VRd treated front line patients relapse at month 30 -50% of BCMA bispecific patients relapse at month 11-15 (Tecvayli/Elrexfio) Then there are limited options for BCMA-exposed multiple myeloma patients (no approved drugs) BCMA-exposed multiple myeloma excluded from CAR-T trials (Arcellx, Carvykti, Abecma) IMMİX BIOPHARMA Shortening hospital stay (from 15-day average to 3 days) Today, only 5% of hospitals can dose CAR-T primarily due to neurotoxicity and cytokine release syndrome Enabling clinical testing of NXC-201 in earlier lines of therapy Presentations at the American Society of Cell and Gene Therapy, publications in Haematologica and others Mature clinical dataset Precedents for open-label, single-arm FDA approvals at ~100 patient dataset - Carvykti, Abecma 75% tumor shrinkage at 2 months in stage 4 MSS relapsed/refractory colorectal cancer ($27 billion market) 4 months median progression-free survival in soft tissue sarcoma ($3bn market), median 7 prior lines of therapy CEO prior clinical investigator for GSK and Eli Lilly registrational clinical trials (including TRELEGY® ELLIPTAⓇ). CFO led NASDAQ IPO and has raised significant capital, former Goldman Sachs and Columbia University Immix Biopharma and Nexcella board members include former Pfizer Chairman/CEO and those from Prometheus/Merck ($11bn); ChemoCentryx/Amgen ($4bn); Sierra/GSK ($2bn); Tobira/AbbVie ($2bn) Scientific Advisory Board from leading medical research institutions: Harvard, Stanford, Memorial Sloan Kettering Chief Medical Officer team led and participated in clinical trials leading to regulatory approvals of: CAR-Ts KYMRIAH® (Novartis) and TECARTUS® (Kite/Gilead); PERJETA® (Roche), TECENTRIQ® (Roche), BESPONSAⓇ (Pfizer), RITUXAN® (Genentech/Biogen) 3#4Neurotoxicity Restricts CAR-T Adoption Parkinson's Like Symptoms (can develop after 3 months) Limited Hospital Access (can only be dosed in 5% hospitals in the US) CAR-T Neurotoxicity Long Hospital Stay (average -14 days) Patient Deaths (On FDA Appproval Labels) ●●● IMMIX S BIOPHARMA 4#5Nexcella Resolves Neurotoxicity No Parkinson's Like Symptoms Broad Hospital Access (can access vast majority of hospitals in the US) Resolving CAR-T Neurotoxicity Short Hospital Stay (average-3 days) No Deaths Across 58 Patients in Clinical Trial ●●● IMMIX S BIOPHARMA 5#6NXC-201 Is Overcoming Prolonged CRS and Neurotoxicity Neurotoxicity (%) Median CRS Onset (Days) Median CRS Duration (Days) Range CRS Duration (Days) Number of patients (n) NXC-201 I I I 4% 1 1-7 50 NXC-201 Low neurotoxicity vs. -20-30% for others ARCELLX CART-ddBCMA 23% 2 5-8 3-13 31 Johnson Johnson CARVYKTI (ciltacabtagene autoleuce) 23% 7 1-40 97 ll Bristol Myers Squibb Abecma (idecabtagene vicleuce) 28% 1 7 1-63 127 ●●● S IMMIX BIOPHARMA Source: Carvykti and Abecma FDA labels, Arcellx Corporate Presentation. Assayag, N., et al. European Society for Blood and Marrow Transplantation 49th Annual Meeting. Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HB10101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting, 2023.. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. Figures reflect cross-trial comparison and not results from a head-to head study. 6#7Outpatient Access To NXC-201 Potentially Increases CAR-T Addressable Market by 10-20x Today - CAR-T Treatment Options NXC-201 Treatment Options I I Today: CAR-T is accessible at only 5% I of US hospitals, mostly academic I research centers in major cities L CLINIC 00 CLINIC I **** I I + HOSPITAL 884 CLINIC +HOSPITAL 884 Future: NXC-201 potentially accessible at many more US hospitals, academic research centers in cities + regional medical centers and clinics -- ■ CLINIC 00 1000 + HOSPITAL +884 CLINIC 01 +HOSPITAL 884 I I I I CLINIC + HOSPITAL 188 BA CLINIC +HOSPITAL ■ CLINIC I ■ 000 ●●● IMMIX So BIOPHARMA +884 + HOSPITAL CLINIC 0 +HOSPITAL 88k CLINIC ■ Source: Sharma A, et al, Epidemiology and Predictors of 30-Day Readmission in CAR-T Cell Therapy Recipients. Transplant Cell Ther. 2023 Feb;29(2):108.e1-108.e7. doi: 10.1016/j.jtct.2022.11.004. Epub 2022 Nov 9. PMID: 36371048. George Washington University "The Differences Between Academic and Community Medical Centers"#8N-GENIUS Technology Platform – Proprietary COBRA Binding Domain Is a Differentiated Innovation Abecma 4-11 CD32 Carvykti 4-1BB CD3( Note: Graphic representation. COBRA = Codon Optimized Binder for Receptor Antigens - Proprietary Binding Domain CART- ddBCMA 4-1BB CD3( NXC-201 with COBRA Binding Domain 4-1BBY CD32Y N-GENIUS EXPAND Technology ●●● S IMMIX BIOPHARMA 8#9NXC-201 MoA: Next Generation CAR-T For Multiple Myeloma and AL Amyloidosis BCMA EXPRESSING CANCER CELL NXC-201 CAR-T CELL ● NXC-201: FIRST BCMA CAR-T GENERATED BY THE N-GENIUS PLATFORM NXC-201 BCMA Surface Expression NXC-201 BCMA Chimeric Antigen Receptor (CAR) NXC-201 is a next-generation chimeric antigen receptor (CAR) T-cell (CAR-T) produced by our N-GENIUS platform targeting B-cell maturation antigen (BCMA) High Overall Response Rates in AL Amyloidosis and Multiple Myeloma First Outpatient CAR-T: Short CRS duration (median 1 days) starting on day 1 THPT LID لسل NXC-201 - Key Characteristics High Transduction Efficiency (Lower dose may lead to lower toxicity) *Carvykti data presented at ASH 2019; Abecma data presented at ASH 2017. CART-ddBCMA source Arcellx. Analysis based on cross-trial comparisons of publicly available data reported in ASH 2017 and 2019 and not a head-to-head clinical trial Low Tonic Signaling (Lower off-target toxicity may lead to lower toxicity) NXC-201 was co-cultured with the indicated target T cells and TNFx (B) and IL-2 (C) concentrations secreted in the culture supernatant were determined by ELISA. Anti-Exhaustion Capability (Increased Persistence may lead to efficacy over an extended period of time) NXC-201 was co-cultured overnight then analyzed by flow cytometry for the expression of 4-1BB % CAR+ TNFa (pg/mL) 100% 80% 60% 150 40% 20% 0% 6,000 5,000 4,000 3,000 2,000 1,000 0 Caryvikti No target 4.5±1.8 10 10⁰ 10² 10³ 104 No Target ●●● IMMIX S BIOPHARMA Abecma CART-ddBCMA 100 Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421. 101 T NXC-201 K562-BCMA 57.7 ±3.2 103 K562-BCMA 104 9#10N-GENIUS Technology Platform - NXC-201 rapidly eliminates relapsed/refractory multiple myeloma tumors, driving dramatically improved tolerability (1/2) NXC-201 Median onset range of duration of CRS Median onset range of duration of ICANS neurotoxicity Johnson & Johnson CARVYKTI™ (citacabtagene autoleucell Baseline SBCMA -460,000 pg/mL Ill Bristol Myers Squibb™ Median onset range of duration of CRS Median onset range of duration of ICANS neurotoxicity Abecma (idecabtagene vicleuce) Baseline SBCMA -500,000 pg/mL Baseline SBCMA -203,000 pg/mL Median onset range of duration of CRS Median onset range of duration of ICANS neurotoxicity 1 1 2 1-7 CRS duration Zero neurotoxicity sBCMA AUC sBCMA AUC CAR-T cells CAR-T cells 30 days 1-40 CAR-T cells SBCMA area under the curve (AUC) CRS duration 1-63 ICANS Neurotoxicity duration 60 days CRS duration ICANS Neurotoxicity duration CAR-T cell expansion in the blood -Relative SBCMA tumor marker level in blood --Limit of Quantitation, SBCMA 2-297 1-578 Days since CAR-T cell infusion NXC-201 Produces Deepening Response Transformations Day 200-240 After Treatment (median 5.7 months of follow-up as of Feb 9 2023 data cutoff) Pt. 23 Day 240 VGPR → CR 10-5 Pt. 11 Day 225 VGPR MRD+ → VGPR MRD- Pt. 22 Day 200 VGPR CR 10-5 155 days ●●● S IMMİX BIOPHARMA 1 NXC-201: Max 7-day CRS Others: up to 63 day CRS 2 NXC-201: Low (4%) Neurotoxicity Others: Up to 578-day neurotoxicity 3 NXC-201: SBCMA reduced in ~30 days Others: SBCMA reduced in -60-155 days 4 NXC-201: CAR-T cells exit body after sBCMA reduced Others: CAR-T cells remain elevated, causing prolonged neurotoxicity and CRS *NXC-201: No measurements available beyond 30 days in multiple myeloma as of the Feb 2023 data cutoff (in human data from AL Amyloidosis, NXC-201 clears system in < 30days as seen on the next slide) 10 Source: FDA labels; company presentations; EMA assessment report; Asherie, N., et al. Haematologica, 2022. Frigault, M., et al. Blood Advances, 2022; Shen, Y, et al. Curr Res Transl Med. 2023; Janssen Science; Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies; Y-axes units (log10) for T-cell expansion: cells/mL blood (NXC-201) and vector transgene copies/ug of genomic DNA (Carvykti, Abecma), for relative SBCMA: 0-200 (NXC-201), ng/mL (Abecma) and pg/mL (Carvykti); Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023.#11N-GENIUS Technology Platform - NXC-201 rapidly eliminates diseased AL Amyloidosis plasma cells and exits within 30 days (2/2) HB10101 cell/m L Blood HB10101/mL Blood 30 days 2×105. 1.5x105- 1x105- 5x104- 1 0 dFLC (mg/L) 0 20 40 60 Days to CART infusion 80 600 400 · 200 0 dFLC (mg/L) ●●● IMMIX S BIOPHARMA *dFLC (=involved FLC-un involved FLC) Source: NXC-201 (formerly known as HBI0101). Nexcella ASGCT Presentation Los Angeles 2023. E. Lebel et al. Feasibility of a Novel Academic Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI10101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting. 2023. 11#12Nature of AL Amyloidosis Diseased AL Amyloidosis Plasma Cells Express BCMA Target On Cell Surface AL Amyloidosis Is Caused By Malignant Plasma Calls That Produce Misfolded Amyloid Protein ... Bone marrow 1) PLASMA CELL/ MATURE B CELL CLONE Circulation 2) NATIVE LIGHT CHAINS Misfolding/ oligomerization 3) AMYLOID FIBRILS 4) CELL DAMAGE Target tissues/endothelium Which Damages Primary Organs Including: Heart, Liver, Kidney Heart • Heart failure with preserved ejection fraction • Thickened ventricular walls and low voltages on electrocardiography • Dysponea at rest or exertion, fatigue • Hypotension or syncope • Peripheral oedema Source: Merlini, G., et al. Nat Rev Dis Primers. Oct 2018, Front. Cardiovasc. Med., Dec 2022, Hemato 2022, 3(1), 47-62; https://doi.org/10.3390/hemato3010005 ●●● IMMIX S BIOPHARMA Liver • Increased alkaline phosphatase • Hepatomegaly Kidney • Nephrotic range proteinuria • Renal failure • Peripheral oedema 12#13NXC-201 - First CAR-T in AL Amyloidosis, a $6 billion market by 2025 Johnson & Johnson DARZALEX (daratumumab) 22% in a sus fue 00 mm 400 mg/20 m 55% Investigator's Choice NM response rates in relapsed/refractory AL Amyloidosis NXC-201 I Best Hematologic Response and I Cardiac Response NM AstraZeneca CAELUM BIOSCIENCES CAEL-101 100% Hematologic Overall Response Rate prothena Birtamimab - 39% NXC-201 35% I 61% Median Reduction from baseline NT-proBNP ● ●●● IMMIX S BIOPHARMA NXC-201 Only CAR-T in AL Amyloidosis NXC-201 100% Overall Response Rate in relapsed/refractory AL amyloidosis (median 6 lines of therapy prior to NXC-201 - all including Darzalex) Cardiac Response exceeds purpose-designed CAEL-101 and Birtamimab for relapsed/ refractory patients Zero Neurotoxicity of any grade in AL Amyloidosis Birtamimab Source: Gertz MA et al. J Clin Oncol. 2016;. CAEL-101 source: Edwards CV, et al. Blood. 2021 Darzalex source: Theodorakakou, et al, 2022-Outcomes of Patients with AL Amyloidosis after Failure of Daratumumab-Based Therapy - Blood (2022) 140 (Supplement 1): 4275-4276 https://doi.org/10.1182/blood-2022-165403, Point-of-care CART manufacture and delivery: Expanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9-11. Assayag, M, et al. Stepensky. Point-of-care CART manufacture and delivery for the treatment of multiple myeloma and AL amyloidosis: the experience of Hadassah Medical Center. Poster Presentation, European Society for Blood and Marrow Transplantation 49th Annual Meeting. 2023 Apr 23-26. Asherie N. et al, Oral Presentation. ASGCT, 2023.The Amyloidosis market was $3.6 billion in 2017, expected to reach $6 billion in 2025, according to Grand View Research. Lebel E, et al. Feasibility of a Novel Academic Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting, 2023. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies.. Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. 13#14Only CAR-T in BCMA-exposed multiple myeloma, a rapidly growing patient segment (1/2) Representative Treatment Results Representative patient number growth Newly diagnosed Bortezomib, lenalidomide, and (VRD) is stand dex therapy for newly diagnosed multiple myeloma -50% relapse at month 30 Standard-of-care refractory BCMA-targeted antibodies (Tecvayli-J&J; Elrexfio-Pfizer) bispecifics -50% relapse at month 11-15 ●●● IMMIX S BIOPHARMA BCMA-exposed, a rapidly growing patient segment Limited treatment options (no approved treatments) NXC-201: 75% overall response rate; 50% complete response rate "Recent studies of anti-BCMA BsAbs, ... demonstrate that patients may experience disease progression after treatment, leaving them with few other treatment options." Cohen et al, Blood, 2023 Source: https://doi.org/10.1038/s41591-023-02528-9 Nature Medicine, Lancet Oncol. 2020 October; 21(10): 1317-1330. doi:10.1016/S1470-2045(20)30452-6, ; Teclistamab in Relapsed or Refractory Multiple Myeloma New England Journal of Medicine Aug 11 2022. Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. Cohen et al 2023 https://doi.org/10.1182/blood.2022015526 14#15Only CAR-T in BCMA-exposed multiple myeloma, a rapidly growing patient segment (2/2) Complete Response Rates in BCMA-exposed multiple myeloma NXC-201 50% NXC-201 67% improvement in response rates Johnson-Johnson Bristol Myers Pfizer Squibb CARVYKTI™ Iciltacablagene autoleuce 2022 I 30% Abecma (decabragene vicleuce) 2021 FDA approval year 29% ELREXFIO (elranatamab-bcmm) 2023 34% ●●● IMMIX S BIOPHARMA Source: 49th EBMT (NXC-201) presentation, Elrexfio FDA approval label, Cohen et al 2023 https://doi.org/10.1182/blood.2022015526 Blood 2022 https://doi.org/10.1182/blood-2022-164884. Note: Elrexfio reflects overall response rate (complete response rate not reported on FDA label). Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. 15#16NXC-201 Clinical Development Plan Through FDA BLA Submissions Expansion Into Additional Sites in the U.S. Planned for Q4 2023/01 2024 Target Indication Relapsed/refractory AL Amyloidosis NXC-201 BCMA-exposed multiple myeloma NXC-201 Phase 1b/2a NXC-201 Ongoing: NEXICART-1 (NCT04720313) Phase 1b/2a NXC-201 Ongoing: NEXICART-1 (NCT04720313) Phase 2a Open Label, Potentially Pivotal Trial Recommended Phase 2 Dose (RP2D) Already Established at 800 million NXC-201 CAR+T Cells Trial Relapsed/refractory Light Chain (AL) Amyloidosis >30 Patients Relapsed/refractory Multiple Myeloma 97 patients Proof-of-concept clinical At RP2D data to be generated in 2nd line therapy Submit to FDA (BLA) Clinical Effectiveness Submit to FDA (BLA) ●●● IMMIX S BIOPHARMA Status -25% Patients Dosed -50% Patients Dosed FDA approval precedents include: Abecma/BMS (single arm study 100 patients in efficacy results population, FDA approved 2021); Carvykti/J&J (single arm study 97 patients in efficacy results population, FDA approved 2022); Elrexfio/Pfizer (single arm study 97 patients in efficacy results population, FDA approved 2023) 16#17IMX-110 Clinical Results Demonstrate Potential for Best-in-Class Efficacy & Safety in Soft Tissue Sarcoma (STS), and Encouraging Efficacy in Colorectal Cancer 100% Relapsed/Refractory Soft Tissue 68% Sarcoma 62% 4.2 2.7 2.6 ht. 58% Disease Control at 2 months IMX-110 7L Johnson-Johnson Yondelis (trabectedin 2L 4.0 median PFS (months) Doxorubicin 1L 3L Eisai Relapsed/Refractory Metastatic pMMR Colorectal Cancer Halaven d 75% NR (1% ORR reported) 2.0 2.0 Tumor Shrinkage median PFS (months) IMX-110 + PD-19L B BAYER K Stivarga fragorafenibles 4L ● ● ● ●●● IMMIX S BIOPHARMA IMX-110 category leading progression free survival (PFS) in heavily pretreated patients with zero drug-related SAES IMX-110 100% Disease Control at 2 months (Doxorubicin 68% Yondelis 62% Halaven 58%) IMX-110 treated STS patients had 3-13 median prior lines of therapies IMX-110 + PD-1 treated r/r colorectal cancer showed 75% tumor shrinkage and mPFS not reached (NR) at 2 months in patients had 8 median prior lines of therapies Note: mPFS is Median Progression Free Survival. Dollar amounts are annual drug sales. Adapted from: Lorigan et al. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 2007 Jul 20;25(21):3144-50. doi: 10.1200/JCO.2006.09.7717. Judson et al. Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol. 2014 Apr;15(4):415-23. doi: 10.1016/S1470-2045(14)70063-4. Chawla et al. First-Line Aldoxorubicin vs Doxorubicin in Metastatic or Locally Advanced Unresectable Soft-Tissue Sarcoma: A Phase 2b Randomized Clinical Trial. JAMA Oncol. 2015 Dec;1(9):1272-80. doi: 10.1001/jamaoncol.2015.3101. Tawbi et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol. 2017 Nov;18(11):1493-1501. doi: 10.1016/S1470-2045(17)30624-1. D'Angelo et al. Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol 2018 Mar;19(3):416-426. doi: 10.1016/S1470- 2045(18)30006-8. Schöffski et al. Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet. 2016 Apr 16;387(10028):1629-37. doi: 10.1016/S0140-6736(15)01283-0. D'Angelo et al. Pilot study of NKTR214 and nivolumab in patients with sarcomas. Journal of Clinical Oncology 2019 37:15_suppl, 11010-11010. DOI: 10.1200/JCO.2019.37.15_suppl.11010. van der Graaf et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012 May 19;379(9829):1879-86. doi: 10.1016/S0140-6736(12)60651-5. Epub 2012 May 16. Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. The global soft tissue sarcoma market is estimated to reach USD 6,465.7 million by 2030 from USD 2,943.3 million in 2019 according to MedGadget. Per Stirvarga FDA approval label, Stivarga 1% Overall Response Rate (ORR) reported, tumor shrinkage not reported. pMMR: proficient mismatch repair 17#18Upcoming Catalysts I NXC-201 ✓2023 - Ongoing Phase 1b/2 results with NXC-201 Data pending release: relapsed/refractory Multiple Myeloma - 63 patients treated ✓ Data pending release: relapsed/refractory AL amyloidosis - 9 patients treated ✔ Data pending release: More patients (current enrollment pace -5 patients/month) ✓2023 - Pre-IND meeting with FDA ✓2023 - File IND for U.S. Phase 1b/2 trial for NXC-201 I✓ 2023 Q4 - US clinical trial open ✓1H25 - Planned Biologics License Applications (BLA) submission for NXC-201 once 100 patients are dosed IMMIX BIOPHARMA ●●● IMMIX S BIOPHARMA IMX-110 ✓ 2023 - Release data on a rolling basis from Phase 1b/2a advanced solid tumor trial with IMX-110 + tislelizumab combination therapy ✓ 2023 - Continue enrolling patients into Phase 1b/2a trial evaluating IMX-110 in STS ✓ 2023 - Ongoing preclinical studies with IMX-110 ✓2023 - Add Phase 2a clinical sites for IMX-110 ✓ 2024 - Report Phase interim 2a results for IMX-110 I in STS Other Candidates ✓ 2H23 - Finish preclinical studies with IMX-111 ✓ 2H23 - Finish preclinical studies with IMX-120 18#19N-GENIUS Platform + IMMIXBio™ SMARXT Tissue-Specific™ Platform HIM N-GENIUS PLATFORM 3 Key Elements Purpose-Built Cell Therapy Evidence Capture Engine + Relational Database Relating Nexcella internal data to external to accelerate therapy design, manufacture, and preclinical Proprietary EXPAND technology Applied to multiple cell therapy indications, already utilized to create NXC-201, to potentially increase efficacy and tolerability Atomized, Novel Binding Scaffold Generation Engine Allows us to make the correct binding for every molecule Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421. TME Normalization™ Technology - SMART Tissue-Specific Platform Oncology Application 3 Pillars Benefit ●●● IMMIX S BIOPHARMA 1 System-Tissue Biology Model Development 2 3 Purpose-Built Physical Biochemistry Engine Predictive Validation Framework Robust MOAS in Complex Pathologies Generate Actionable Drug Candidates Highly Predictive IND-Enabling Activities 19#20ImmixBio Pipeline Summary Stage Clinical Preclinical Tx Type CAR-T TSTX CAR-T CAR-T TSTX TSTX Candidate NXC-201 target BCMA ¡MX-110 TME Normalization™ Technology NXC-301 NXC-401 iMX-111 iMX-120 Indication Multiple Myeloma AL Amyloidosis Soft Tissue Sarcoma Solid Tumors, Colorectal + Tislelizumab (anti-PD-1) ALL, LBCL, MCL AML Colorectal Cancer Inflammatory Bowel Disease Preclinical Phase 1b/2a Ongoing Phase 1b/2a Ongoing Phase 1b/2a Ongoing Phase 1 Phase 1b/2a Ongoing Preclinical Preclinical Preclinical Preclinical Phase 2 Phase 3 Approval Collaboration BeiGene Progress 63 patients treated 95% overall response rate US FDA Orphan Drug Designation (ODD) for Multiple Myeloma Granted . 9 patients treated in relapsed/refractory AL Amyloidosis • 100% overall response rate • 67% complete response rate . ●●● IMMIX S BIOPHARMA US FDA Orphan Drug Designation (ODD) for AL Amyloidosis Granted US FDA Orphan Drug Designation (ODD) for STS Granted US FDA Rare Pediatric Disease Designation (RPDD) Granted Zero drug-related SAES CMC: 7 GMP batches manufactured to-date In preclinical development EXPAND technology In preclinical development EXPAND technology Tissue Specific Biologic™ Targeted biomarker GLUT1 overexpressed in stage 3/4 colorectal cancer and additional tumor types Tissue Specific Biologic™ 12-month end-to-end clinical trial leading to potential approval in multi billion-dollar indication Global Rights **** +00 do BIOPHARMA IMMIX O IMMIX ... 60 BIOPHARMA • +00 • *00 000 59 •[00 *** sp 00 5 O 00 +00 50 0 *** IMMIX BIOPHARMA IMMIX BIOPHARMA IMMİX BIOPHARMA IMMIX BIOPHARMA IMMIX BIOPHARMA IMMİX BIOPHARMA 20 Note: 95% overall response rate in multiple myeloma isf or patients without prior BCMA targeted therapies. Treatment. Source: Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023.. Lebel E, et al. Feasibility of a Novel Academic Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting. 2023. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies.#21NXC-201 Entering Large Markets At a Pivotal Moment Hematologic cancers market opportunity is $60bn today growing to $120bn in 2028. ● Market Size Multiple Myeloma ("MM") is 3rd most common blood cancer, impacting 176,404 patients annually, with life expectancy of 5 years. AL Amyloidosis is developed by 14,982 people annually-with no available treatments as standard of care other than bone marrow transplant (only 20% patients eligible) Hematologic Cancers Market Size $120B... Darzalex/ Carvykti/ Daratumumab Cilta-cel Johnson & Johnson Johnson-Johnron $60B... Abecma/ Ide-cel Bristol Myers Squibb Venclexta/ Venetoclax abbvie Ninlaro/ Kyprolis/ Ixazomib Carfilzomib Birtamimab Takeda AMGEN prothena 1 2 3 "Patients With Multiple Myeloma May Face CAR T-Cell Shortages" The ASCO Post Sep 25, 2022 4 Best ORR CR/SCR Why Now Leveraging market CAR-T experience so far-manufacturing consistency, automation technology, efficacy, safety. Demand for MM CAR-Ts continues to exceed supply - only 2 MM CAR-Ts on the market: Ill Bristol Myers Squibb Abecma decobtogene vicleucell . NXC-201 800 x 106 CAR+T cells 95% "Gilead lands new cell therapy for Kite in $225M Arcellx deal, providing global scale for future J&J-Legend showdown" Dec 9, 2022 Bispecifics/Allogeneic CAR-Ts still work in progress. 1 61% Still common with approved CAR-Ts: High grade Cytokine Release Syndrome grade 3) and neurotoxicity side-effects. ●●● IMMIX S BIOPHARMA CARVYKTI (ciltacabtagene autoleucell Allogeneic BCMA-CAR-T 71% 25% FIERCE Biotech BCMA bispecific engagers 75% 43% Sources: Multiple Myeloma life expectancy source - Arcellx July 2022 investor presentation (NADSAQ:ACLX). Multiple myeloma annual incidence source: GLOBOCAN 2020. Hematologic cancers market size source: reportsanddata.com. AL Amyloidosis annual incidence source: Global epidemiology of amyloid light-chain amyloidosis https://doi.org/10.1186/s13023-022-02414-6. AL Amyloydosis transplant eligibility source: Bone Marrow Transplant. 2013 Oct;48(10):1302-7. doi: 10.1038/bmt.2013.53; Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting, 2023. Note: Allo BCMA CAR-T scope includes ALLO-715 (Allogene); CYAD-211 (Celyad), BCMA Bispecific Engagers scope includes Teclistamab (Janssen); Elranatamab (Pfizer); ABBV-383 (AbbVie); REGN5458 (Regeneron); CC-93269 (Bristol Myers); HPN217 (Harpoon) as of March 1 2022. 21#22Potential to Disrupt the $230bn+ Oncology and Immunology Categories 2030 Market Opportunity Broad platforms driving next-generation therapies in blood cancers, solid tumors and immunology MULTIPLE MYELOMA $29B+ CELL THERAPY PD-1 ANNUAL SALES - KEYTRUDAⓇ + OPDIVOⓇ $29 B SOLID TUMORS + IMMUNOLOGY AL Amyloidosis $4B+ CELL THERAPY CELL THERAPY Hematologic Malignancies Acute lymphocytic leukemia Large B-Cell Lymphoma Mantle Cell Lymphoma Acute Myeloid Leukemia ●●● IMMIX S BIOPHARMA SOLID TUMORS + IMMUNOLOGY Soft Tissue Sarcoma Colorectal Cancer Inflammatory Bowel Disease $175B+ Sources: Hematologic cancers market size source: reportsanddata.com. Merck Financial Results, 2022 Bristol Meyers Squibb Financial Results. AL Amyloidosis market size according to Grand View Research. Hematological Malignancies reportsanddata.com, ALL alliedmarket research.com, LBCL datamintelligence.com, MCL dataintelio.com, AML GlobalData, STS MedGadget, CRC Industry Arc, Prometheus Biosciences S-1. 22#23:: BIOPHARMA Lead Cell Therapy Candidate NXC-201#24NXC-201 Clinical Results Demonstrate Potential for Best-in-Class Efficacy & Safety in AL (light chain) Amyloidosis Patient #s Hematologic Overall Response Rate | Hematologic Complete Response Rate Hematologic CR + VGPR I Cardiac response - (NT-proBNP median reduction) Renal response (%) Median prior lines of therapy % pretreated with CD38-targeted treatment (Darzalex/other) Relapsed/Refractory Light chain (AL) Amyloidosis Source NXC-201 NEXCELLA NEXT GENERATION CELL THERAPIES NXC-201 Monotherapy One-Time Treatment n=9 100% 67% 89% 61% 50% 6 100% 29th ASGCT 2023, 49th EBMT Meeting 2023, 5th European CAR-T Meeting, Clinical Cancer Research 20th IMS Meeting 2023 Johnson & Johnson DARZALEX (daratumumab) i Darzalex Combination (combined with cyclophosphamide, bortezomib, and/or dexamethasone) Weekly treatments n=9 22% 0% 22% 1 100% Investigator's Choice (Darzalex comination with bortezomib or IMiD, venetoclax, belantamab mafodotin, bortezomb- baaed, lenalidomide-based, ptpomalidomide, ixazomib or alkylating agent) n=31 55% ? 45% Landscape 1 100% AstraZeneca CAELUM BIOSCIENCES CAEL-101 Weekly treatments n=10 (renal) n=24 (cardiac) 39% 20% 2 ? ●●● S Blood 2021 IMMİX BIOPHARMA prothena Birtamimab Birtamimab Combined with SOC CyBorD Weekly treatments N = 14 (cardiac) N = 15 (renal) Theodorakakou, et al, Blood 2022 Theodorakakou, et al, Blood 2022 14,982 patient annual incidence Birtamimab Source: Gertz MA et al. First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction. J Clin Oncol. 2016 Apr 1;34(10):1097-103. doi: 10.1200/JCO.2015.63.6530. Epub 2016 Feb 8. PMID: 26858336; PMCID: PMC5470113. (Birtamimab development was paused + restarted). CAEL-101 source: Edwards CV, et al. Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis. Blood. 2021 Dec 23;138(25):2632-2641. doi: 10.1182/blood.2020009039. PMID: 34521113; PMCID: PMC8703360.. Darzalex source: Theodorakakou, et al, 2022 - Outcomes of Patients with AL Amyloidosis after Failure of Daratumumab-Based Therapy-Blood (2022) 140 (Supplement 1): 4275-4276 https://doi.org/10.1182/blood-2022-165403, Point-of-care CART manufacture and delivery: Expanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9-11. Assayag M, et al. Point-of-care CART manufacture and delivery for the treatment of multiple myeloma and AL amyloidosis: the experience of Hadassah Medical Center. Poster Presentation, European Society for Blood and Marrow Transplantation 49th Annual Meeting. 2023 Apr 23-26. Asherie N. et al, BCMA- Targeted CART (HBI0101), a Safe and Efficacious Novel Modality of Treatment for Light Chain Amyloidosis (AL) Patients. Oral Presentation. ASGCT-American Society of Gene & Cell Therapy 29th Annual Meeting. May 19, 2023. Figures reflect cross-trial comparison and not results from a head-to head study. Lebel E,et al. Feasibility of a Novel Academic Anti-BCMA 24 Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting, 2023. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. 35% 60% 2 0% Gertz, et al. JCO 2016#25NXC-201 Clinical Results Demonstrate Potential for Best-in-Class Efficacy & Safety in Multiple Myeloma, a $29 billion market by 2027 71% Complete Response Rate in Relapsed/Refractory Multiple Myeloma 78% 48% No BCMA 61% ARCELLX NASDAQ: ACLX CART-ddBCMA 30% 29% Yes BCMA Johnson & Johnson CARVYKTI™ Iciltacabtagene autoleucell 50% Bristol Myers Squibb™ 28% Overall NXC-201 58% ● ● ●●● S IMMIX BIOPHARMA NXC-201 Class leading efficacy in multiple myeloma NXC-201: low (4%) neurotoxicity grade 1-2 (9- 23% for others) • -80% reduction in hospitalization cost - 3 day hospital stay for NXC-201 (14 days for others) Abecma lidecabtagene vicleuce) "Yes/No BCMA" refers to prior treatment with BCMA-targeted therapies. "Overall" includes a mix of Yes/No Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421., Feasibility of a Novel Academic BCMA-CART (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis. Clin Cancer Res. 2022 Dec 1;28(23):5156-5166. doi: 10.1158/1078-0432.CCR-22-0637. PMID: 36107221., Point-of-care CART manufacture and delivery: zExpanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting, 2023 Feb 9-11. Assayag M, et al. Stepensky. Point-of-care CART manufacture and delivery for the treatment of multiple myeloma and AL amyloidosis: the experience of Hadassah Medical Center. Poster Presentation, European Society for Blood and Marrow Transplantation 49th Annual Meeting. 2023 Apr 23-26. Blood 2022 https://doi.org/10.1182/blood-2022-164884. Cohen et al 2023 https://doi.org/10.1182/blood.2022015526. E. Lebel et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies. The $13.9 billion Multiple Myeloma market in 2017 is expected to reach $28.7 billion in 2027 according to Wilcock, et al. Nature Reviews. Figures reflect cross-trial comparison and not results from a head-to head study.. 25#26NXC-201 Clinical Results Demonstrate Potential for Best-in-Class Efficacy & Safety in Multiple Myeloma Patients Clinical Data No Prior BCMA-Targeted Therapy Patient #s Extramedullary disease (EMD) High risk cytogenetics Overall Response Rate Complete Response Rate ICANS Neurotoxcity (all grades) CRS, grade >= 3 Potential hospital stay length based on available data Source NEXCELLA HEXATION CLL THE planned RP2D 800 million CAR+T cells NXC-201 Monotherapy n=38 24% 62% 95% 61% -3 days 49th EBMT Meeting 2023 20th IMS Meeting 2023 ARCELLX (NASDAQ: ACLX) CART- ddBCMA 100 + 300M cells n=31 39% 100% 71% 23% 3% -14 days 2022 NASDAQ IPO S-1 Johnson Johnson CARVYKTI fittacattajent autoleucell n=97 13% 24% 98% 78% 23% (2 deaths) 5% (1 death) -14 days FDA Approval Label Bristol Myers Squibb Abecma lidecatogene videoe n=144 50% 36% 88% 48% 8.5% -14 days Ferreri et al, Blood 2022 NEXCELLA Yes Prior BCMA-Targeted Therapy planned RP2D 800 million CAR+T cells NXC-201 Monotherapy n=12 24% 62% 75% 50% 0% -3 days 49th EBMT Meeting 2023 Investigator's choice N=275 ? 29% 31% 2% N/A N/A N/A Gandhi, et al 2019 Johnson Johnson CARVYKTI (citacabtagere autoleucel n=20 25% 15% 60% 30% 20% 0% -14 days Blood 2023 - Cohen et al Bristol Myers Squibb Abecma (decabtogene vicleuce) n=49 50% 36% 74% 29% 8.5% 2% -14 days Ferreri et al, Blood 2022 Overall - Mixed (BCMA Pretreated + not) NEXCELLA HET GENERATION CELL THERAP includes all patients (with and without Prior BCMA-Targeted Therapy) treated at 800 million CAR+T cells NXC-201 Monotherapy n=50 24% 62% 90% 58% 4% 14% -3 days ●●● IMMIX S BIOPHARMA 20th IMS Meeting 2023 Ill Bristol Myers Squibb™ Abecma (idecabtagene vicleuce) n=100 36% 37% 72% 28% 28% 9%² (1 death) 14 days FDA Approval Label 176,404 (35,730 US) patient annual incidence ¹All grades of neurotoxicity 2 The safety data described in this section reflect the exposure to ABECMA in the KarMMa study, in which 127 patients with relapsed/refractory multiple myeloma received ABECMA. 3a3bFor of the first 20, 42 patients treated with NXC-201 at all doses, respectively Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421, Feasibility of a Novel Academic BCMA-CART (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis. Clin Cancer Res. 2022 Dec 1;28(23):5156-5166. doi: 10.1158/1078-0432.CCR-22-0637. PMID: 36107221., Point-of-care CART manufacture and delivery: zExpanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9- 11. Assayag M, et al. Point-of-care CART manufacture and delivery for the treatment of multiple myeloma and AL amyloidosis: the experience of Hadassah Medical Center. Poster Presentation, European Society for Blood and Marrow Transplantation 49th Annual Meeting. 2023 Apr 23-26. Blood 2022 https://doi.org/10.1182/blood-2022-164884. Cohen et al 2023 26 https://doi.org/10.1182/blood.2022015526. Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting, 2023. Figures reflect cross-trial comparison and not results from a head-to head study. Differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across studies.#27NXC-201 Clinical Highlights: 4% Neurotoxicity Across 50 Patients; Outpatient CAR-T Potential Relapsed/refractory Multiple Myeloma 95% Overall Response Rate in Heavily Pretreated Multiple Myeloma Patients 61% CR/SCR rate Low (4%) Neurotoxicity observed No Grade 4 Cytokine Release Syndrome (CRS) Observed at planned RP2D 800 million CAR+T cells Outpatient CAR-T Potential Published in Haemotologica 2022 + 5th European CAR-T Cell Meeting + EBMT 49th Annual meeting + 20th IMS Data in 63 patients so far ll Bristol Myers Squibb Revlimid Ronaldomidoves $11Bn Annualized Sales Johnson & Johnson DARZALEX (daratumumab) A Ill Bristol Myers Squibb Pomalyst foomalioomide) capsules 1-2-3-4 mg $2.5Bn Annualized Sales $8Bn Annual Sales Ill Bristol Myers Squibb Abecma fidecubungene viceucel FDA Approved Anti-BCMA Autologous CAR-T 176,404 patient annual incidence Johnson & Johnson CARVYKTI™ [ciltacabtagene autoleucel) FDA Approved Anti-BCMA Autologous CAR-T Relapsed/refractory Light chain (AL) Amyloidosis 100% Overall Response + 67% Complete Response in Relapsed/Refractory Amyloidosis Patients, 1 responder with 16+ months PFS Duration of Response Not Yet Reached at a median follow-up of 7.3 months 2-stage improvement in NYHA stage was observed with NXC-201 Median 61% reduction in NT-proBNP from baseline ●●● IMMİX S BIOPHARMA Outpatient CAR-T Potential Published in Clinical Cancer Research 2022 + 5th European CAR-T Cell Meeting + 49th EBMT meeting + 29th ASCGT 2023 (Los Angeles) + 20th IMS 2023 Data in 9 patients so far Johnson-Johnson DARZALEX (daratumumab) 10 $8Bn Annual Sales 14,982 patient annual incidence Source: BMS First Quarter 2022 financial results; "Genmab Improves Its 2022 Financial Guidance' November 3 2022, Celgene Second Quarter 2019 Operating and Financial Results., Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.2816: Epub ahead of print. PMID: 36200421., Feasibility of a Novel Academic BCMA-CART (HB10101) for the Treatment of Relapsed and Refractory AL Amyloidosis. Clin Cancer Res. 2022 Dec 1;28(23):5156-5166. doi: 10.1158/1078-0432.CCR-22-0637. PMID: 36107221., Point-of-care CART manufacture and delivery: Expanding access to CART therapy via local institutions, Hadassah Medical Center experience. Posti Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9-11. Assayag M, et al. Point-of-care CART manufacture and delivery for the treatment of multiple myeloma and AL amyloidosis: the experience of Hadassah Medical Center. Poster Presentation, European Society for Blood and Marrow Transplantation 49th An Meeting. 2023 Apr 23-26. Lebel E, et al. Feasibility of a Novel Academic Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HB10101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting 202. Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsec Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023.#28Proportion of NXC-201 Patients with SCR/CR Increased Over Time in Relapsed/Refractory Multiple Myeloma 100% 80% 60% 40% 20% 0% 50% 31% 2% 17% ■ Best response in patients with at least 1 month follow up SD PR VGPR 75% 25% SCR/CR Best response in patients with at least 6 months follow up 83% 17% ●●● IMMIX S BIOPHARMA Best response in patients with at least 9 months follow up The patients included in this analysis are determined by those who have had their 1- (n=42), 6 - (n=16), 9 - (n=6) month follow-up visits, respectively, per protocol. Source: Point-of-care CART manufacture and delivery: Expanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Bloo28 and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9-11., Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421., Note: SD = Stable Disease; PR = Partial Response; VGPR = Very Good Partial Response; SCR = stringent (10-5) Complete Response; CR = Complete Response#29Adverse Event Profile - NXC-201 Adverse Events Cytokine Release Syndrome (CRS) Day of median onset (min-max) Days of median duration (min-max) Immune cell associated Neurotoxicity (ICANS) Day of median onset (min-max) Day of median duration (min-max) Toxicity Management | Tocilizumab | Dexamethasone NXC-201 150x10 CAR+T cells n=6 Grade 3 0 (0%) 0 (0%) of n=6 1 (17%) 0 (0%) NXC-201 450x10 CAR+T cells n=7 Grade 3 0 (0%) 0 (0%) of n=7 4 (57%) 0 (0%) Grade 1-2 41 (82%) 1 2 (4%) NXC-201 800x10 CAR+T cells n=50 of n=50 40/48 (83%) 8/48 (17%) ●●● IMMIX S BIOPHARMA Grade 3 7 (14%) 2 0 (0%) Note. No Grade 4 CRS with NXC-201. Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421, Point-of-care CART manufacture and delivery: Expanding access to CART therapy via local institutions, Hadassah Medical Center experience. Poster Presentation, European Society for Blood and Marrow Transplantation and European Hematology Association 5th European CAR T-cell Meeting. 2023 Feb 9-11, Nexcella, Inc. E. Lebel et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023. 29#30Adverse Event Profile - NXC-201 Market Adverse Events Cytokine Release Syndrome (CRS) Day of median onset (min-max) Days of median duration (min-max) Immune cell associated Neurotoxicity (ICANS) Day of median onset (min-max) Day of median duration (min-max) Toxicity Management Tocilizumab Dexamethasone Source: Arcellx July 2022 Corporate Presentation. ICANS of any grade ARCELLX 100 x10 cells n=25 Grade 3-4 0 (0%) 2 (1-8 days) 8 (3-13 days) 6 (24%) 4.5 (3-6 days) 7.5 (4-11 days) 19 (76%) 13 (52%) ARCELLX 300x10' cells n=6 Grade 3-4 1 (17%) 2 (1-2 days) 5 (3-10 days) 1 (17%) 7 days 23 days 5 (83%) 2 (33%) ●●● S BIOPHARMA IMMIX 30#31Ongoing Clinical Study Design Recommended Phase 2 Dose (RP2D) Already Determined at 800x10^6 150x10^6 CAR+ T cells (NEXICART-1/NCT04720313) in Multiple Myeloma N=6 450x10^6 CAR+ T cells N=7 As of September, 2023 800x10^6 CAR+ T cells N=50 ●●● IMMIX S BIOPHARMA RP2D already determined at at 800x10^6 50 patients in MM 9 in AL ►Dosing ongoing... Source: 8 patients treated in relapsed/refractory AL amyloidosis as of May 11, 2023, 5 at 800 x10^6 cells, 2 at 250 x10^6 cells, 1 at 150x10^6 cells. Multiple Myeloma data cutoff at February 9th, 2023. Lebel E, et al. Feasibility of a Novel Academic Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis, International Myeloma Society 20th Annual Meeting. 2023. Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023. 31#32:: BIOPHARMA Lead TSTX Candidate IMX-110#33IMX-110 MoA: Tissue-Specific Therapeutic™ with TME Normalization™ Technology www. ● ● IMX-110: FIRST TARGETED ONCOLOGY MICELLE TO ACHIEVE "SMALL MOLECULE PENETRATION" - www -PEG-PE -DOX - CUR www. www. O 14-16nm diameter wwwww. IgG Antibody: 10-15nm diameter www. BCL-x BCL -my arvivi IMX-110 PI3K AKT Upregulation in Cancer ¡MX-110 Downregulation. |||||| || 0 O NFKB COX2 spase 0 Jak STAT Cell Death O ¡MX-110 DNA Damage IMX-110 Upregulation 0 ¡MX-110 Disperses Throughout Cell TUPT Lil IMX-110 - Key Characteristics Get There: Deliver Payload Deep Into the Tumor Microenvironment Stay There: Accumulate in Tumors % of dose / g organ Kill Tumors: 12x Tumor Killing vs SoC 1% Control 1 0 intensity (a.u.) (g) 600 -12nm -60nm -125nm 200 15% -200 10 10 20 30 Time (h) Free DOX ●●● S 40 80 distance from vessel (um)-> (Adapted from Popovic et al, 2010) 40 IMMIX BIOPHARMA IMX-110 is a negatively-charged Tissue-Specific Therapeutic™ built on our TME Normalization™ Technology encapsulating a synergistic 5:1 ratio of poly-kinase inhibitor (polyphenol curcuminoid complex, or PCC) and apoptosis inducer (PEG-PE doxorubicin complex) delivered deep into the TME. First Oncology Micelle to achieve "small molecule penetration" Electrostatic charge attracts to tumor like a magnet Resulting in 1,200% increase in apoptosis (tumor cell death) vs. conventional therapies 33 Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol. 2022.281628. Epub ahead of print. PMID: 36200421. Stan, S. D. et al. Nat. Rev. Gastroenterol. Hepatol. 7, 347-356 (2010); published online 4 May 2010. http://www.nature.com/doifinder/10.1038/nrgastro.2010.61. Popovic et al, A nanoparticle size series for in vivo fluorescence imaging. Angew Chem Int Ed Engl. 2010 Nov 8; 49(46): 8649-8652. https://dx.doi.org/10.1002%2Fanie.201003142; M Yokoyama, T Okano, Y Sakurai, S Fukushima, K Okamoto, K Kataoka. Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. https://doi.org/10.3109/10611869909085500; Sarisozen et. al. (2016- https://doi.org/10.1016/j.ejpb.2016.08.013). Caspase 3/7 Increase (%) vs. Control (empty micelle) as an indicator of tumor apoptosis, after 24h 1,200% increase 181% penetration depth 35% Micellular DOX Free DOX 53% DOX micelles. CUR micelles iMX-110#34IMX-110 Preclinical Data Provides Translational Rationale & PD-1 Combination Rationale 50% 0% (50%) (100%) Percent Survival After One Cycle of Treatment At Day 22 75% IMX-110 Demonstrated Improved Survival iMX-110 IMX-110 Demonstrated Response Rate Better than Standard of Care Best % Change from Baseline in Size of Tumor +23% Trabectedin (sold as YONDELIS by Janssen, a Johnson & Johnson Company) 0% (41%) Standard of Care IMX-110 Treatment Treatment Group: Group: Responder Entire Group Mean (32%) ¡MX-110 Treatment Group: Entire Group Mean In a connective tissue cancer Soft Tissue Sarcoma (STS) mice study, IMX-110 was compared against approved drugs • One cycle of IMX-110 produced 75% survival vs. 0% survival for Trabectedin (sold as YONDELIS® by Janssen, a Johnson & Johnson Company, a U.S. FDA approved drug) May 20, 2022 Press Release • IMX-110 produced a 50% response rate after 1 cycle of treatment as a monotherapy in first-line- therapy-resistant cancer soft tissue sarcoma (STS) mice study • IMX-110 response rate surpassed standard of care doxorubicin's response rate of 0% after 1 cycle of treatment in the same study January 12, 2022 Press Release ● Median Survival In Genetic (KPC) Pancreatic Cancer Mouse Model IMX-110 +anti-PD-1 Potential Survival Benefit Better than Comparable Median Survival 63 days IMX-110 + anti-PD-1 IMMIX BIOPHARMA A50%! 05070 42 days 4-drug combination 2 chemotherapies (gemcitabine, nab-paclitaxel) and 2 immunotherapies (anti-PD-1, anti-CD40) Source: Inmix Biopharma, Inc. Adapted from Winograd, et al, 2015 January 25, 2022 10:15 ET | Source: Immix Biopharma, Inc. ●●● ● BIOPHARMA • IMX-110 + anti-PD-1 produced 63-day median survival in a genetic (KPC) pancreatic cancer mouse model in which mice develop their own pancreatic cancer and have an intact immune system ● Historically, 42-days is the median survival produced by a 4-drug combination of 2 chemotherapies and 2 immunotherapies in the same genetic pancreatic cancer mouse model according to Winograd et al., 2015 • 2022 plan to commence combination IMX- 110 + BeiGene anti-PD-1 tislelizumab Phase 1b/2a clinical trial in advanced solid tumors January 25, 2022 Press Release IMX-110 + anti-PD-1 Combination Produced Extended Median Survival in Genetic Pancreatic Cancer Mouse Model, Bolstering Planned 2022 IMX-110 Combination Clinical Trial Rationale 34 5#35Clinical Trial and Supply Agreement with BeiGene for Tislelizumab (Anti-PD-1 mAb) ● IMMIX ΒΙΟΡΗΑR ΜΑ Study Goal Demonstrate the potential for TSTX to be an integral component of combination therapies for a wide range of advanced solid tumors Rapid IMX-110 expansion into additional oncology indications By eliminating immunosuppressive T-regulatory immune cells IMX-110 ● MAN Combination Trial Design ¡MX-110 + tislelizumab (anti-PD-1) BeiGene 30 patient Phase 1b study across advanced solid tumors enabling cytotoxic T- lymphocytes to enter the tumor of Scientific Basis: IMX-110 turns “cold” tumors “hot” in genetic (KPC) mouse models of pancreatic cancer IMX-110 + murine anti-PD-1 survival exceeded by exactly 50% a 4-drug combination (anti-PD-1/anti-CD40/nab-paclitaxel/gemcitabine) in a genetic pancreatic cancer (KPC) mouse model in the literature ●●● S ¡MX-110 Joint Alliance Committee IMMIX BIOPHARMA A Joint Alliance Committee consisting of members from ImmixBio & BeiGene will coordinate the clinical trial and eliminating tumor vascularization. As of June 2021, in China, tislelizumab has already been approved or granted conditional approved in 5 cancer indications, including non-squamous non- small cell lung cancer ("NSCLC"), squamous NSCLC, classical Hodgkin's lymphoma, Hepatocellular Carcinoma, and urothelial carcinoma (Source: BeiGene Businesswire Press Release "China NMPA Approves Tislelizumab in Non-Small Cell Lung Cancer and Hepatocellular Carcinoma" Dated Jun 23, 2021) iMX-110 35#36iMX-110 Pancreatic Preclinical KPC Mouse Model: (iMX-110 + PD-1) Outperforms (Gem + Pac + PD-1 + CD-40) Median Survival Comparison | Pdx1-Cre (KPC mice) Panc Model mOS (Days) IMMIX IMX-110 + PD-1 Perelman SCHOOL OF MEDIMINE Usestry of PENYANA CD40/G/NP + PD-1 63 1 450% 42 IMMIX Immix Biopharma Unpublished Data KPC Mice Survival (90 Days) 120 Dosing Schedule IMX-110 aPD-1 80 40 0 120 80 40 Dosing Schedule Gemcitabine (G) nab-Paclitaxel (np) aPD-1 aCD40 0 0 Pancreatic Pdx1-Cre (KPC mice) Model - ¡MX-110 + PD-1 Combination 4 ▲▲▲▲▲ A A A T 8 12 16 20 24 28 32 36 40 44 48 52 56 60 64 68 72 76 80 84 88 92 96 100 Days from Enrollment A Perelman Winograd et al; Cancer Immunol Res. 2015 Apr;3(4):399-411. UTY of PANTA KPC Mice Survival (90 Days) AAAAA A ▲ A AAAAA A A A IMX-110 + PD-1 (n=3) Isotype Alone (n=6-8) CD40/G/nP (n=6-8) 0 4 8 12 16 20 24 28 32 36 40 44 48 52 56 60 64 68 72 76 80 84 88 92 96 100 Days from Enrollment Source/Adapted from: Immix Biopharma, Inc. Winograd et al. Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Cancer Immunol Res..2015 Apr;3(4):399-411. doi: 10.1158/2326-6066.CIR-14-0215. Epub 2015 Feb 12. Immix Biopharma Dosing: IMX-110 dosed based on doxorubicin at 1.5 mg/kg, aPD-1 (RMP1-14; BioXcell) 100µg/dose Winograd, et al Dosing: gemcitabine (Eli Lilly) 120 mg/kg, nab-paclitaxel (Sigma) 108 mg/kg, aCD40 (FGK45; BioXcell) 100μg/dose, aPD-1 (RMP1-14; BioXcell) 200µg/dose PD-1 alone (n=6-8) CD40/G/nP+ PD-1 (n=6-8) Individual Mice - Luciferase activity (tumor growth) activity ●●● IMMİX S BIOPHARMA Mouse A 1663 (pdx1-Cre) ¡MX-110 + PD-1 Mouse B 1689 (p48-Cre) Perelman SCHOOL OF MEDICINE ¡MX-110 + PD-1 IMMIX ¡MX-110 (n=3) All Mice Tumor Frequency 100% 100% 36#37:: BIOPHARMA Lead TSTX Candidate IMX-110: IMMINENT-01 Clinical Trial Data#38IMX-110 1b/2a Data: Tumor Shrinkage in 75% of Heavily Pretreated Soft Tissue Sarcoma Patients | | I I % Change in Target Lesion Size from Baseline Week 16 Week 24 100% 80% 60% 20% 40% Progressive Disease (PD) Threshold 0% Soft Tissue Sarcoma | iMX-110 Monotherapy Baseline ¡MX-110 (20%) I (40%) Partial Response (PR) Threshold | (60%) I (80%) | (100%) I Week 8 2 Month PFS 5th line therapy 4 Month PFS 9th line therapy 4 Month PFS (6 month radiological PFS) 4th line therapy 6 Month PFS 14th line therapy 31cm tumor diameter across 5 target lesions Patient Indication | Dose Soft Tissue Sarcoma | 8.4 -Soft Tissue Sarcoma | 10.4 Soft Tissue Sarcoma | 10.4 Soft Tissue Sarcoma | 9.6 Best % Change from Baseline in Size of Target Lesions 26% -10% -17% -18% Dosing Schedule- | 100% Non-Sarcoma Cancers | iMX-110 Monotherapy 80% 60% 40% 20% 0% (20%) % Change in Target Lesion Size from Baseline Baseline Week 8 Week 24 Week 32 Compassionate Use PD Threshold 4 Month PFS Colorectal 14th line therapy iMX-110 PD Threshold (40%) PR Threshold (60%) (80%) (100%) ●●● S Week 16 E IMMIX BIOPHARMA PR Threshold - Colorectal | 5.0 Wk 40 Patient Indication | Dose Nasopharyngeal | 3.4 Colorectal | 5.0 Breast 10.4 Colorectal | 1.4 Source: Immix Biopharma, Inc. ImmixBio has evaluable data for the 8 patients as of October 2021 (out of n=15, 6 did not complete any tumor measurements after enrolment scan, 1 was dosed in Dec 2022). All 8 evaluable patients have discontinued treatment. "Heavily Pretreated" refers to 3-13 lines of therapy. Dose on far right for each patient expressed in mg/m². 38#39IMX-110 Opportunity: Soft Tissue Sarcoma - Remains An Unmet Medical Need Select Approved Therapies & Clinical Trials in Soft Tissue Sarcoma mPFS (months) 5 4 3 2 1 0 -20% Judson DOX 14 Chawla DOX '15 Lorigan DOX '07 0% ران gsk Pazopanib NOVARTIS 20% MERCK Pembrolizumab Bristol Myers Squibb Nivolumab + Ipilimumab 40% Eisai Eribulin Bristol Myers Squibb Nivolumab 60% 80% 100% STS Sub-Indication Drugs Used To Treat Soft Tissue Sarcoma Leiomyosarcoma Liposarcoma Undifferentiated Pleomorphic Sarcoma (Adapted From In et al, 2017) Disease Control @ 2 mos Median Progression Free Survival Dose Interruptions due to Toxicity Drug-Related SAEs Overall Response Rate % Of Patients With ≥ 3 Lines Of Treatment Prior to Therapy Note: mPFS is Median Progression Free Survival Dollar amounts are annual drug sales. Adapted from: Lorigan et al. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 2007 Jul 20:25(21):3144-50. doi: 10.1200/3CO.2006.09.7717. Judson et al. Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol. 2014 Apr;15(4):415-23. doi: 10.1016/S1470- 2045(14)70063-4. Chawla et al. First-Line Aldoxorubicin vs Doxorubicin in Metastatic or Locally Advanced Unresectable Soft-Tissue Sarcoma: A Phase 2b Randomized Clinical Trial. JAMA Oncol. 2015 Dec;1(9):1272-80. doi: 10.1001/jamaoncol 2015.3101. Tawbi et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol. 2017 Nov;18(11):1493-1501, doi: 10.1016/S1470-2045(17)30624-1. D'Angelo et al. Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol. 2018 Mar;19(3):416-426. doi: 10.1016/S1470-2045(18)30006-8. Schöffski et al. Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet 2016 Apr 16,387(10028):1629-37. doi: 10.1016/S0140-6736(15)01283-0. D'Angelo et al. Pilot study of NKTR214 and nivolumab in patients with sarcomas. Journal of Clinical Oncology 2019 37:15_suppl, 11010-11010. DOI: 10.1200/JC0.2019.37.15 suppl 11010. van der Graaf et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012 May 19,379(9829):1879-86. doi: 10.1016/S0140-6736(12)60651-5. Epub 2012 May 16. 1st Line single-agent doxorubicin (generic) doxorubicin and ifosfamide (generic) liposomal doxorubicin (generic, 1995 JJ) 68% 2.7 months ? 18% 0% Doxorubicin (Chawla et al, 2015) 2nd Line Gemcitabine docetaxel (generic) Trabectedin (2015) Gemcitabine + docetaxel (generic) 62% 4.2 months 57% 13% ●●● S 10% (0% CR) Trabectedin (Demetri et al, 2015) IMMIX BIOPHARMA 3rd Line Trabectedin (2015) Eribulin (2010) Pazopanib (2009) 58% 2.6 months 33% 8% 4% (0% CR) Eribulin (Schöffski et al, 2016) Note: CR is Complete Response. Adapted from: Chawla et al. First-Line Aldoxorubicin vs Doxorubicin in Metastatic or Locally Advanced Unresectable Soft-Tissue Sarcoma: A Phase 2b Randomized Clinical Trial. JAMA Oncol. 2015 Dec;1(9):1272-80. doi: 10.1001/jamaoncol.2015.3101. Demetri et al, Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial. J Clin Oncol. 2016 Mar 10;34(8):786-93. doi: 10.1200/3CO.2015.62.4734. Epub 2015 Sep 14. Schöffski et al. Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet. 2016 Apr 16:387(10028):1629-37. doi: 10.1016/S0140-6736(15)01283-0. In et al, Treatment of advanced, metastatic soft tissue sarcoma: latest evidence and clinical considerations. Ther Adv Med Oncol. 2017 Aug;9(8):533-550. doi: 10.1177/1758834017712963. Epub 2017 Jun 15. 39#40IMX-110 Clinical Data: 4-month mPFS in Late Stage Sarcoma, Well Tolerated IMX-110 Median Progression Free Survival in Late Stage STS mPFS (months) LO 5 4 months 3 2 1 0 0% (note: IMMIX n=4) 20% 40% 60% IMMIX ¡MX-110 4 month mPFS across 100% heavily pre-treated soft tissue sarcoma patients 80% % Of Patients With ≥ 3 Lines Of Treatment Prior to Therapy 100% STS Sub-Indication Leiomyosarcoma Liposarcoma Undifferentiated Pleomorphic Sarcoma ImmixBio iMX-110 Clinical Trial Disease Control @ 2 mos Median Progression Free Survival Dose Interruptions due to Toxicity Drug-Related SAEs Overall Response Rate Median 7th Line (4-14th Line) IMMIX iMX-110 100% 4 months 0% 0% 0% iMX-110 (ImmixBio Unpublished) ●●● IMMIX S BIOPHARMA 14th Line Patient IMMIX ¡MX-110 100% 6 months 0% 0% 0% ¡MX-110 (ImmixBio Unpublished) 40#41IMX-110: Direct Path To 1st Line Therapy in STS - Clinical Trial Plan iMX-110 Monotherapy ¡MX-110 + tislelizumab (anti-PD-1) combination Phase 1b iMX-110 Ongoing Phase 2a iMX-110 30 patients End of Phase 2a Phase 1b iMX-110 + tislelizumab (anti-PD-1) 30 patients BeiGene Trial Relapsed/refractory advanced solid tumors 1st Line Therapy Advanced STS Relapsed/refractory advanced solid tumors ¡MX-110 Establish MTD / RP2D iMX-110 at RP2D iMX-110 + tislelizumab Establish MTD / RP2D & NOVARTIS ●●● S IMMİX BIOPHARMA Status Ongoing Ongoing 41#42:: BIOPHARMA Preclinical Candidates#43Cell Therapy Platform HIM 3 Key Elements Purpose-Built Cell Therapy Evidence Capture Engine + Relational Database Relating Nexcella internal data to external to accelerate therapy design, manufacture, and preclinical Proprietary EXPAND technology Applied to multiple cell therapy indications, already utilized to create NXC-201, to potentially increase efficacy and tolerability Atomized, Novel Binding Scaffold Generation Engine Allows us to make the correct binding for every molecule N-GENIUS PLATFORM NXC-201 CAR-T CELL NXC-301 CAR-T CELL BCMA EXPRESSING CANCER CELL NXC-401 CAR-T CELL NXC-201 CAR-T CELL CANCER CELL NXC-301 CAR-T CELL CANCER CELL Source: Development and manufacturing of novel locally produced anti-BCMA CART cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results. Haematologica. 2022 Oct 6. doi: 10.3324/haematol.2022.281628. Epub ahead of print. PMID: 36200421. Lebel E, et al. Efficacy and Safety of a Locally Produced Novel Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) (HBI0101) for the Treatment of Relapsed and Refractory Multiple Myeloma, International Myeloma Society 20th Annual Meeting. 2023. NXC-401 CAR-T CELL Produced NXC-201, NXC-301, NXC-401 BCMA Surface Expression 1 NXC-201 BCMA I Chimeric Antigen Receptor I (CAR) I I Surface Expression I. NXC-301 I Proprietary Chimeric I Antigen Receptor I (CAR) I I Surface Expression NXC-401 Proprietary I Chimeric Antigen Receptor I (CAR) NXC-201 is a next-generation chimeric antigen receptor (CAR) T-cell (CAR-T) targeting B-cell maturation antigen (BCMA) High Complete Response Rates in AL Amyloidosis and Multiple Myeloma ● First Outpatient CAR-T: Short CRS duration (median 1 day) starting on day 0 4% neurotoxicity NXC-301 is a next-generation CAR-T with a proprietary target. Indications: ● ●●● IMMİX S BIOPHARMA ● ● Acute lymphocytic leukemia (ALL) Large B-Cell Lymphoma (LBCL) Mantle cell lymphoma (MCL) NXC-401 is a next-generation CAR-T with a proprietary target. Indications: Acute Myeloid Leukemia (AML) 43#44IMMIXBio™M SMARXT Tissue-Specific™ Platform Oo FIM TM TME Normalization™ Technology – SMARXT Tissue-Specific Platform Oncology Application 3 Pillars System-Tissue Biology Model Development Purpose-Built Physical Biochemistry Engine Predictive Validation Framework IMX-110 IMX-111 BIOLOGIC IMX-120 BIOLOGIC www. UT-1 SCFV GLUT-1 scFv 8 wwww Effector molecules Produced IMX-110, IMX-111, IMX-120 AWA www -PEG-PE -DOX -CUR www. ww www. -PEG-PE -DOX -CUR NO DO -PEG-PE www O ∞ www www- O ●●● S BIOPHARMA IMMİX is a negatively-charged Tissue-Specific Therapeutic™ built on our TME NormalizationTM Technology encapsulating a synergistic 5:1 ratio of poly-kinase inhibitor and apoptosis inducer delivered deep into the TME First Oncology Micelle to achieve "small molecule penetration Electrostatic charge attracts to tumor like a magnet ● Resulting in 1,200% increase in apoptosis (tumor cell death) vs. conventional therapies is a Tissue-Specific Biologic™M built on our TME Normalization™ Technology with proprietary GLUT1 antibody biomarker targeting facilitating preferential accumulation in glucose-consuming cancer cells. Indication: Colorectal Cancer (CRC) is a Tissue-Specific Biologic™M with Immune Normalization Technology encapsulating anti-inflammatory poly-kinase inhibitors (polyphenols) with proprietary targeting (GLUT1/ confidential targets) selectively silencing disease- causing inflammatory bowel immune cells. 44#45IMX-111: GLUT1 Biomarker-targeted for Colorectal Cancer iMX-111 is a Tissue-Specific Biologic™ built on our TME Normalization Technology with proprietary GLUT1 antibody biomarker targeting facilitating preferential accumulation in glucose-consuming cancer cells such as colorectal cancer. ImmixBio Proprietary GLUT-1 scFv antibody www. wwww.. -PEG-PE =DOX =CUR wwwww www. ¡MX-111 www. www. www. www wwwww www. www 17-23nm diameter IgG Antibody: 10-15nm diameter 01 ¡MX-111's GLUT1 target is overexpressed on Colorectal and other cancers 02 GLUT1 is associated with poor prognosis in colorectal cancer 03 100% survival @ 24 days vs. 0% control survival in colorectal cancer xenograft model Percentage of tumors with increased GLUT1 expression compared to non-tumorous tissue (Adapted from Amann, 2009) % Survival I+II 100 Overexpression of GLUT1 Associated With Stage 3/4 Colorectal Cancer (Shen, 2011) Dosing Schedule ¡MX-111 80 60 40 20 0 0 2 III+IV 4 A 6 A Brain (glia cell) Esophagus Colon/rectum 8 Ovarian Stomach Bile duct Lung A Endometrium Breast Colorectal Cancer Stage Relative Value of GLUT1 Expression in colorectal cancer PBS - Control 10 12 14 16 A Healthy Normal Colon No/ Light GLUT1 Staining HCT-116 CRC Xenograft Model: Survival Curve 18 ●●● IMMIX S BIOPHARMA (Adapted from Haber, 1998) ¡MX-111 72% 71% 3 92% 86% 86% 81% 76% 100% 100% Source: Adapted from Abouzeid, et. al. Anti-cancer activity of anti-GLUT1 antibody targeted polymeric micelles co-loaded with curcumin and doxorubicin (2013 - https://doi.org/10.3109/1061186x.2013.840639); Shen, et al. Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis. Int J Biol Markers. Jul-Sep 2011;26(3):166-72. doi: 10.5301/JBM.2011.8550. Epub 2011 Jul 22. Amman, et al. GLUT1 as a therapeutic target in hepatocellular carcinoma. Expert Opin Ther Targets. 2009 Dec;13(12):1411-27. doi: 10.1517/14728220903307509; Haber, et al. GLUT1 Glucose Transporter Expression in Colorectal Carcinoma: A Marker for Poor Prognosis. Cancer. 1998 Jul 1;83(1):34-40. doi: 10.1002/(sici)1097-0142(19980701)83:1<34::aid- cncr5>3.0.co;2-e. Colorectal Carcinoma Heavy GLUT1 Staining 20 22 24 26 28 30 32 34 36 38 40 42 Days After Initial Treatment (Adapted from Abouzeid et al, 2013) 45#46iMX-111 Preclinical Data in TNBC Breast & Colorectal Cancer: Immix Biopharma Therapies Produce Rare Tumor Shrinkage/Stability Effective in Doxorubicin resistant MDA-MB-231 TNBC Breast Cancer Cell Line... Dosing Schedule ¡MX-110 250 200 150 100 50 0 MDA-MB-231 Xenograft Model: Tumor Volume after 7 injections PBS Control Dosing Stop I I I GLUT1-CUR+DOX Micelles 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 52 ▲▲▲▲▲▲ iMX-111 Tumor inhibition studies of various micellar formulations. Nude mice bearing -150 mm³ MDA-MB-231 tumors were treated every 2 days starting at Day 20 except last injection administered at day 33 (7 total IV injections) at a dose of 6 mg/kg CUR and 1 mg/kg DOX. N26 with SEM (Adapted from Abouzeid et al, 2014). . And Effective in HCT-116 Colorectal Cancer Cell Line Which Is Not Typically Treated With Doxorubicin 1400 1200 1000 800 600 400 200 0 Dosing Schedule iMX-110 100 80 60 40 20 0 Dosing Schedule iMX-110 HCT-116 Xenograft Model: Tumor Volume & Survival Curve after 14 day treatment (7 injections) 0 2 0 2 A A 4 4 6 6 A 8 A 8 A -PBS - Control Dosing Stop I 10 12 14 16 18 20 | 1 10 12 14 A 16 18 20 T 22 GLUT1-CUR+DOX Micelles + I 22 24 26 24 26 iMX-111 ●●● IMMİX S BIOPHARMA Days After Initial Treatment 28 30 32 34 36 38 40 42 Adapted from: Abouzeid, et. al. Anti-cancer activity of anti-GLUT1 antibody targeted polymeric micelles co-loaded with curcumin and doxorubicin (2013 - https://doi.org/10.3109/1061186x.2013.840639); Abouzeid et al, Nanotechnology-based treatment for chemotherapy-resistant breast cancer. SPIE 9166, Biosensing and Nanomedicine VII, 916606 (27 August 2014); doi: 10.1117/12.2064660. Measurements + SD. ¡MX-111 Days After Initial Treatment Tumor inhibition studies of various micellar formulations. Female nude (NU/NU) mice bearing 250mm³ HCT-116 tumors were treated every 2 d starting at day 0 (7 total tail vein injections, arrows correspond to injection days) at a dose of 4 mg/kg CUR and 0.4 mg/kg DOX. N = 6 with SEM. Empty micelle dose was equivalent to the amount of lipid from the drug-loaded micelle groups. A - Tumor volume. B- Survival curve, survival was determined when the tumor reached 1000mm³ (Adapted from Abouzeid et al, 2013) 46#47IMX-120 GLUT1 Biomarker-targeted for Inflammatory Bowel Disease iMX-120 is a Tissue-Specific BiologicTM with Immune Normalization Technology encapsulating anti- inflammatory poly-kinase inhibitors (polyphenols) with proprietary targeting (GLUT1/ confidential targets) selectively silencing disease-causing inflammatory bowel immune cells. ¡MX-120 confider GLUTF1 scFv www. w -PEG-PE Effector molecules www ww www. www. www. www www. 17-23nm diameter "fistulas are a very disabling manifestation and source of morbidity for Crohn's disease (CD) patients...the cumulative incidence of perianal fistulas in CD range from 23% to 38% ... treatment of perianal CD requires a combined surgical and medical approach" (Adapted from Marzo et al, 2015) 01 iMX-120 effector polyphenols have shown promise in IBD clinical studies 02 GLUT1/ confidential targeting, selectively silencing disease-causing IBD immune cells ■Curcumin + Mesalamine ("Curcumin") 65% Glucose Ulcerative Colitis Oral Curcumin + SOC Produced Responses & Remissions Far Exceeding SOC Alone (n=50) Response wk 4 (Adapted from Lang et al, 2015). Glut1 Lactate 13% 54% 0% Remission wk 4 Glycolytic-M1 GLYCOLYSIS (mTOR, HIF-1a) -ATP معلول ول ولك iMX-120 targeting halts pro-inflammatory immune effects ROS ATP Glutamine GLUTAMINOLYSIS Mesalamine Alone ("Placebo") Gut KE epithelium ‒‒‒‒‒‒‒‒ 45% Endoscopic response wk 4 Pro-inflammatory cytokines, lipids & metabolites 0% Glycolytic EVS ROS-HIF-1a HIV CD4 T cell Glucose 2 Recruited Warburg-like monocytes and T cells Model showing potential inflammatory and immunometabolic consequences of gut barrier dysfunction (Adapted from Alzahrani et al, 2019) 36% 0% Endoscopic remission wk 4 Knockout - I Glutl Teff AI Crohn's Disease Oral Curcumin vs Placebo Produced Remissions. (n=30) (Adapted from Sugimoto et al, 2020) Wild-Type CD4 1 TBD GVHD - Theracurmin 35% GLUT1 inhibition significantly reduces IBD/ bowel inflammation in mouse models naive ●●● S Treg 4 week clinical remission rate Glucose (Adapted from Macintyre. et al, 2014) Glycolysis 4 MTOR Growth Proliferation Teff function IMMIX BIOPHARMA Inhibition 0% Inflammation score Placebo +4 PBS m-CPPD MSU PBS IGLUT1 10mg/kg Source: Adapted from Marzo et al, Management of perianal fistulas in Crohn's disease: An up to-date review. World J Gastroenterol. 2015 Feb 7; 21(5): 1394-1403. doi: 10.3748/wjg.v21.15.1394; Lang et al, Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1444-9.e1. doi: 10.1016/j.cgh.2015.02.019. Epub 2015 Feb 24; Sugimoto et al, Highly Bioavailable Curcumin Derivative Ameliorates Crohn's Disease Symptoms: A Randomized, Double-Blind, Multicenter Study. J Crohns Colitis. 2020 May 15. doi: 10.1093/ecco-jcc/jjaa097; Alzahrani et al, Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence andnon-AIDS comorbidities. Lancet EBioMedicine. 2019 Aug;46:522-531. doi: 10.1016/j.ebiom.2019.07.027; Renaudin et al, Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-18 activation on macrophages. Ann Rheum Dis. 2020 Nov;79(11):1506-1514. doi: 10.1136/annrheumdis-2020-217342. Epub 2020 Jul 22; Macintyre et al, The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function. Cell Metab. 2014 Jul 1;20(1):61-72. doi: 10.1016/j.cmet.2014.05.004. Epub 2014 Jun 12. ..Hei: (Adapted from Renaudin et al, 2020) 47#48:: BIOPHARMA Team & Scientific Advisory Board#49World Class Scientific Advisory Board Immix Bio Clinical Advisory Board Select Nexcella Scientific Advisory Board Members ● Larry Norton, MD SVP, Office of the President Medical Director, Evelyn H. Lauder Breast Center, Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center Sant Chawla, MD . Founder, Sarcoma Oncology Research Center JOHN WAYNE CANCER INSTITUTE PrinceSat Jonath Corr THE UNIVERSITY OF TEXAS MD Anderson Cancer Center • Chief, Oncology/ Hematology at UCSD School of Medicine THE UNIVERSITY OF TEXAS MD Anderson Cancer Center Razelle Kurzrock, MD Heather Landau, MD MSK UC San Diego School of Medicine. Hematologic Malignancies • Director, Amyloidosis Program Memorial Sloan Kettering Cancer Center Galit Lahav, PhD • Chair, Department of Systems Biology at Harvard Medical School ● HARVARD MEDICAL SCHOOL Suzanne Lentzsch, do COLUMBIA MD, PHD (Columbia) Hematologic Malignancies Director, Multiple Myeloma and Amyloidosis • UCLA Professor of Oncology Gary Schiller, MD UCLA Health COLUMBIA UNIVERSITY HERBERT IRVING COMPREHENSIVE CANCER CENTER • ●●● IMMIX S BIOPHARMA George Sledge, MD Professor, former Chief, Oncology Division, Stanford Medicine Stanford MEDICINE 49#50Select Leadership Select Leadership Ilya Rachman, MD, PhD Founder & Chief Executive Officer Nexcella Executive Chairman Physician/scientist, co-founded ImmixBio after serving as a clinical investigator for GlaxoSmithKline registrational clinical trials (TRELEGY ELLIPTAⓇ) and Eli Lilly post- approval clinical trials Cedars Sinai UCLA Health UIC COLLEGE OF AT CHICAGO MEDICINE UNIVERSITY OF ILLINOIS Nandan Oza, BS Head of Chemistry, Manufacturing and Control Jazz Pharmaceuticals. • >10 years at Goldman Sachs and other global banks leading mergers & acquisitions, entrepreneur, published research • >20 years extensive CMC experience in organizations ranging from start-ups to large pharmaceutical companies ZOSANO. PHARMA Gabriel Morris, BA Chief Financial Officer Nexcella President COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK TALON PHARMACEUTICALS Goldman Sachs Qi Wen, CFA, MBA Vice President -20 Corporate Strategy Head of Business Development CHICAGO BOOTH The University of Chicagu Booth School of Business • >10 years investment and equity research experience including Bank of America and Jefferies >20 years in clinical drug development, leading clinical trials for pertuzumab (PERJETAⓇ) and leading the clinical filing team for atezolizumab (TECENTRIQ®) at Roche gsk Roche BANK OF AMERICA ●●● IMMIX S BIOPHARMA Jefferies Graham Ross, MBChB, FFPM Chief Medical Officer AstraZeneca 50#51Select Directors Select ImmixBio Board of Directors Members Select Nexcella Board of Directors Members Helen Adams, CPA Former Prometheus Biosciences Board Member Prometheus Deloitte. Pfizer Henry A. McKinnell, PhD Former Pfizer, Inc. Chief Executive Officer MOODY'S Magda Marquet, PhD ALMA Life Sciences ALMA Life Sciences ALTHEA Mary Sue Coleman, Ph.D Former Johnson & Johnson Board Member Johnson & Johnson MICHIGAN Jane Buchan, PhD CEO, Martlet Asset Management KKR J.P.Morgan PRISMA Jeffrey H. Cooper, MBA Former BioMarin Chief Financial Officer BIOMARIN ●●● S IMMIX BIOPHARMA Jason Hsu, PhD Founder & Chairman, Rayliant Global Advisors RAYLIANT research Maffiliates Edward J. Borkowski, CPA MBA Former Mylan Chief Financial Officer m Mylan® 51#52IMMIX Biopharma Investment Highlights First CAR-T in AL Amyloidosis 1 100% overall response rate in relapsed/refractory patients Only CAR-T in BCMA-exposed multiple myeloma, a rapidly growing patient segment 2 3 72 NXC-201 CAR-T patients 4 treated across 9 peer- reviewed publications LO 5 First CAR-T Overcoming Neurotoxicity 6 IMX-110 + PD-1 combination promising results in colorectal cancer with 30 patients dosed World-class team ● Overcoming the most feared side-effect of CAR-T, neurotoxicity: No Parkinson's like symptoms ● ● ● ● ● ●●● S 100% overall response rate in relapsed/refractory AL amyloidosis ($3bn market), median 6 prior lines of therapy No drugs approved in relapsed/refractory AL amyloidosis today -50% of VRd treated front line patients relapse at month 30 -50% of BCMA bispecific patients relapse at month 11-15 (Tecvayli/Elrexfio) Then there are limited options for BCMA-exposed multiple myeloma patients (no approved drugs) BCMA-exposed multiple myeloma excluded from CAR-T trials (Arcellx, Carvykti, Abecma) IMMİX BIOPHARMA Shortening hospital stay (from 15-day average to 3 days) Today, only 5% of hospitals can dose CAR-T primarily due to neurotoxicity and cytokine release syndrome Enabling clinical testing of NXC-201 in earlier lines of therapy Presentations at the American Society of Cell and Gene Therapy, publications in Haematologica and others Mature clinical dataset Precedents for open-label, single-arm FDA approvals at ~100 patient dataset - Carvykti, Abecma 75% tumor shrinkage at 2 months in stage 4 MSS relapsed/refractory colorectal cancer ($27 billion market) 4 months median progression-free survival in soft tissue sarcoma ($3bn market), median 7 prior lines of therapy CEO prior clinical investigator for GSK and Eli Lilly registrational clinical trials (including TRELEGY® ELLIPTAⓇ). CFO led NASDAQ IPO and has raised significant capital, former Goldman Sachs and Columbia University Immix Biopharma and Nexcella board members include former Pfizer Chairman/CEO and those from Prometheus/Merck ($11bn); ChemoCentryx/Amgen ($4bn); Sierra/GSK ($2bn); Tobira/AbbVie ($2bn) Scientific Advisory Board from leading medical research institutions: Harvard, Stanford, Memorial Sloan Kettering Chief Medical Officer team led and participated in clinical trials leading to regulatory approvals of: CAR-Ts KYMRIAH® (Novartis) and TECARTUS® (Kite/Gilead); PERJETA® (Roche), TECENTRIQ® (Roche), BESPONSAⓇ (Pfizer), RITUXAN® (Genentech/Biogen) 52#53:: BIOPHARMA Appendix#54Preconditioning Regimens Lymphodepletion regimen Frequency Infusion (Day 0) from start of lymphodepletion (days) NXC-201 250 mg cyclophosphamide/m² + 25 mg fludarabine/m² QD, days -5, -4, -3 LO 5 Abecma 300 mg cyclophosphamide/m² + 30 mg fludarabine/m² QD, days -5, -4, -3 LO 5 Source: Berdeja JG, et al. Lancet. 2021; Frigault MJ, et al. Blood Adv. 2023; Munshi NC, et al. N Engl J Med. 2021; Asherie N, et al. Haematologica. 2023 Carvykti 300 mg cyclophosphamide/m² + 30 mg fludarabine/m² QD, days -5, -4, -3 5-7 ●●● IMMIX S BIOPHARMA CART-ddBCMA 300 mg cyclophosphamide/m² + 30 mg fludarabine/m² QD, days -5, -4, -3 LO 5 54#55BCMA Bispecific Antibodies (Tecvayli, Elrexfio) Are Currently Being Investigated As An Outpatient Therapy 01 Outpatient Tecvayli "safe and feasible" 02 Administration of Tecvayli will "not be the same as in MajesTEC-1" 03 Clinical trials underway to test outpatient BCMA BsAbs Asya Nina Varshavsky-Yanovsky, MD, PhD Department of Bone Marrow Transplant and Cellular Therapies • Fox Chase-Temple University Hospital Jeffrey Matous, MD • Colorado Blood Cancer Institute • Plasma Cell Diseases Group Trial # Drug Phase azon # pts Start date LOT Primary endpoint "We have treated over 20 patients with our outpatient [Teclistamab dosing] program so far [in r/r MM] ... in conclusion outpatient Teclistamab, step up administration model with close monitoring is safe and feasible in heavily pretreated patients with rrMM allows significant reduction of patient stay which results in healthcare savings and an improvement of patient experience" Aug 4, 2023 "teclistamab has been approved based on the MajesTEC-1 study, where it was given a certain way. I'm convinced that's not how we'll be using teclistamab in the future" May 24, 2023 AJMC NCT05972135 Tecvayli (Teclistamab) 2 50 9/30/2023 Received 4 or more prior therapies Incidence of CRS Yan Ji, MD • HealthPartners Cancer Center at Regions Hospital **EHA PANDIRAL HEMATOLOGY ●●● IMMIX S BIOPHARMA NCT06015542 "We learned how to give patients daratumumab [Darzalex]. Initially, there were a lot of infusion reactions. Now everybody feels very comfortable and we give it to patients all the time" May 10, 2023 Elrexfio (Elranatamab) EHA2023 JUNE 8-16/PMANKFURT & VIRTUAL Targeted Oncology 2 20 1/1/2024 21 proteasome inhibitor, IMID and anti CD-38 mAb Safety 55#56TSTX Market Opportunity Annual Drug Sales (US$ billion) Company KeytrudaⓇ/ pembrolizumab MERCK $33.4bn combined OpdivoⓇ/ nivolumab Oncology (Soft tissue sarcoma, colorectal cancer) Bristol Myers Squibb AvastinⓇ/ bevacizumab Roche Cyramza Ⓡ/ ramucirumab Lilly $0.9bn combined VotrientⓇ/ pazopanib NOVARTIS ●●● IMMIX S BIOPHARMA Halaven Ⓡ/ YondelisⓇ/ eribulin trabectedin дад Eisai Source: Eisai FY2022 Financial Results Presentation, Novartis 2022 Annual Report, 2022 Merck Financial Results, 2022 Bristol Meyers Squibb Financial Results, Roche 2021 Investor Update, Eli Lilly 2022 Financial Results, Abbvie 2022 Financial Results, Johnson & Johnson 2022 Full Year Results, Takeda Annual Securities Report 56#57IMX-120 Opportunity: Inflammatory Bowel Disease (IBD) Market Treatment Arm Placebo Company Clinical Remission Rate at Wk 8 Moderate-to-severe ulcerative colitis (who received concurrent treatment with oral corticosteroids or immunosuppressants) 16.5% 9.3% Humira/adalimumab vs. placebo abbvie Sources: Adapted from Sandborn et al., 2012, Sands et al., 2019, FDA Entyvio® Prescribing Label Clinical Remission Rate at Wk 8 Moderate-to-severe ulcerative colitis 15.6% 5.3% Stelara/ustekinumab vs. placebo Johnson & Johnson ●●● IMMIX S BIOPHARMA Clinical Remission Rate at Wk 6 Moderately to severely active ulcerative colitis 17% 5% Entyvio/vedolizumab vs. placebo Takeda 57